An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration
Zhiyong Sun; Wenguo Cui; Xingzhi Liu; Yanzheng Gu; Lianfu Deng; Helder A. Santos; Guoqing Pan; Hongbo Zhang; Qin Shi; Huilin Yang; Zhongbin Deng; Ruoyu Cheng; Yin Yin
An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration
Zhiyong Sun
Wenguo Cui
Xingzhi Liu
Yanzheng Gu
Lianfu Deng
Helder A. Santos
Guoqing Pan
Hongbo Zhang
Qin Shi
Huilin Yang
Zhongbin Deng
Ruoyu Cheng
Yin Yin
ROYAL SOC CHEMISTRY
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042720091
https://urn.fi/URN:NBN:fi-fe2021042720091
Tiivistelmä
Antibody-based cancer immune therapy has attracted lots of research interest in recent years; however, it is greatly limited by the easy distribution and burst release of antibodies. In addition, after the clearance of the tissue, healthy tissue regeneration is another challenge for cancer treatment. Herein, we have developed a specific immunological tissue engineering scaffold using the agonistic mouse anti-human CD40 antibody (CD40mAb) incorporated into poly(l-lactide) (PLLA) electrospun fibers through the dopamine (PDA) motif (PLLA-PDA-CD40mAb). CD40mAb is successfully incorporated onto the surface of the electrospun fibrous scaffold, which is proved by immunofluorescence staining, and the PLLA-PDA-CD40mAb scaffold has an anti-tumor effect by locally releasing CD40mAb. Therefore, this immunological electrospun scaffold has very good potential to be developed as a powerful tool for localized tumor treatment, and this is the first to be reported in this area.
Kokoelmat
- Rinnakkaistallenteet [19207]