Circulating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults
Sanchez-Delgado Guillermo; Arrizabalaga-Arriazu Cristina; Merchan-Ramirez Elisa; Arias-Tellez Maria Jose; Llamas-Elvira Jose M.; Garcia-Lario Jose V.; Muñoz-Torres Manuel; Ruiz Jonatan R.; Acosta Francisco M.
Circulating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults
Sanchez-Delgado Guillermo
Arrizabalaga-Arriazu Cristina
Merchan-Ramirez Elisa
Arias-Tellez Maria Jose
Llamas-Elvira Jose M.
Garcia-Lario Jose V.
Muñoz-Torres Manuel
Ruiz Jonatan R.
Acosta Francisco M.
SPRINGER
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022081154095
https://urn.fi/URN:NBN:fi-fe2022081154095
Tiivistelmä
Thyroid dysfunction is associated with classic cardiometabolic risk factors in humans. However, this relationship remains unclear in young euthyroid adults. The present work examines the associations of circulating thyroid hormones (THs) and thyroid-stimulating hormone (TSH) concentrations with body composition and cardiometabolic risk factors in young euthyroid adults. A total of 106 sedentary, euthyroid adults (72 women; 22 +/- 2 years old) participated in this cross-sectional study. THs and TSH serum concentrations were determined in fasting conditions (6 h). Body composition (fat mass (FM), lean mass (LM), and visceral adipose tissue (VAT)) was determined by dual-energy X-ray absorptiometry, anthropometric parameters (weight, height, and waist circumference) were measured, and neck adipose tissue mass was quantified through computed tomography (CT) scanning. Cardiometabolic risk factors including fasting glucose and lipid metabolism markers, hepatic phosphatase and transaminases, and blood pressure were also assessed. Free triiodothyronine (FT3) concentration was positively associated with body mass index, LM, VAT, and waist circumference (all P <= 0.038). FT3 was also associated with glucose, insulin, HOMA-IR, fatty liver index, and blood pressure (all P < 0.024). All the associations were attenuated when adjusting for sex. In contrast, we found no associations of TSH or free thyroxine with any body composition parameter or cardiometabolic risk factors. In conclusion, FT3 is associated with central adiposity and cardiometabolic risk factors including insulin resistance, fatty liver index, and mean, systolic and diastolic blood pressure in young euthyroid adults. ClinicalTrials.gov identifier: NCT02365129.
Kokoelmat
- Rinnakkaistallenteet [19207]