Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

Aidan McGlinchey; Tim Sinioja; Santosh Lamichhane; Partho Sen; Johanna Bodin; Heli Siljander; Alex M Dickens; Dawei Geng; Cecilia Carlsson; Daniel Duberg; Jorma Ilonen; Suvi M Virtanen; Hubert Dirven; Hanne F Bentsen; Karin Zimmer; Unni C Nygaard; Matej Oresic; Mikael Knip; Tuulia Hyotylainen
Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

Aidan McGlinchey
Tim Sinioja
Santosh Lamichhane
Partho Sen
Johanna Bodin
Heli Siljander
Alex M Dickens
Dawei Geng
Cecilia Carlsson
Daniel Duberg
Jorma Ilonen
Suvi M Virtanen
Hubert Dirven
Hanne F Bentsen
Karin Zimmer
Unni C Nygaard
Matej Oresic
Mikael Knip
Tuulia Hyotylainen
Katso/Avaa
Lataukset: 

Elsevier
doi:10.1016/j.envint.2020.105935
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042825103
Tiivistelmä

In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers of T1D risk in children. In a mother-infant cohort (264 dyads), high PFAS exposure during pregnancy associated with decreased cord serum phospholipids and progression to T1D-associated islet autoantibodies in the offspring. This PFAS-lipid association appears exacerbated by increased human leukocyte antigen-conferred risk of T1D in infants. Exposure to a single PFAS compound or a mixture of organic pollutants in non-obese diabetic mice resulted in a lipid profile characterized by a similar decrease in phospholipids, a marked increase of lithocholic acid, and accelerated insulitis. Our findings suggest that PFAS exposure during pregnancy contributes to risk and pathogenesis of T1D in offspring.

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