Enhanced Neutralizing Antibody Responses to Rhinovirus C and Age-Dependent Patterns of Infection
Busse William; Holt Patrick; Grindle Kristine; Pongracic Jacqueline; Gergen Peter J; Jartti Tuomas; Kattan Meyer; Fitzpatrick Anne M; Gruchalla Rebecca; Choi Timothy; Hershey Gurjit K. Khurana; Ober Carole; Evans Michael D.; Sly Peter D; Phipatanakul Wanda; Pappas Tressa; Lemanske Jr Robert F; Kercsmar Carolyn; Gern James E.; Patel Shilpa J.; Camargo Jr. Carlos A; Devries Mark; Mauger David T.; Lee Kristine E.; Hasegawa Kohei; Liu Andrew; Bochkov Yury A.; and on behalf of program collaborators for Environmental influences on Child Health Outcomes; Homil Kiara; Wood Robert; Seroogy Christine; Bacharier Len; Kim Haejin; Tisler Christopher; Hartert Tina; Demuri Gregory P; Gangnon Ronald; Wald Ellen R; Cohen Robyn; LeBeau Petra; Le Souëf Peter N.; Laing Ingrid A; Jackson Daniel J
Enhanced Neutralizing Antibody Responses to Rhinovirus C and Age-Dependent Patterns of Infection
Busse William
Holt Patrick
Grindle Kristine
Pongracic Jacqueline
Gergen Peter J
Jartti Tuomas
Kattan Meyer
Fitzpatrick Anne M
Gruchalla Rebecca
Choi Timothy
Hershey Gurjit K. Khurana
Ober Carole
Evans Michael D.
Sly Peter D
Phipatanakul Wanda
Pappas Tressa
Lemanske Jr Robert F
Kercsmar Carolyn
Gern James E.
Patel Shilpa J.
Camargo Jr. Carlos A
Devries Mark
Mauger David T.
Lee Kristine E.
Hasegawa Kohei
Liu Andrew
Bochkov Yury A.; and on behalf of program collaborators for Environmental influences on Child Health Outcomes
Homil Kiara
Wood Robert
Seroogy Christine
Bacharier Len
Kim Haejin
Tisler Christopher
Hartert Tina
Demuri Gregory P
Gangnon Ronald
Wald Ellen R
Cohen Robyn
LeBeau Petra
Le Souëf Peter N.
Laing Ingrid A
Jackson Daniel J
American Lung Association
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042825185
https://urn.fi/URN:NBN:fi-fe2021042825185
Tiivistelmä
Knowledge of prevalent RV types, antibody responses, and populations at risk based on age and genetics may guide the development of vaccines or other novel therapies against this important respiratory pathogen.
Longitudinal data from the Childhood Origins of ASThma (COAST) birth cohort study were analyzed to determine relationships between age and RV-C infections. Neutralizing antibodies specific for rhinovirus A (RV-A) and RV-C (3 types each) were determined using a novel polymerase chain reaction-based assay. We pooled data from 14 study cohorts in the United States, Finland, and Australia and used mixed-effects logistic regression to identify factors related to the proportion of RV-C versus RV-A detection.
In COAST, RV-A and RV-C infections were similarly common in infancy, while RV-C was detected much less often than RV-A during both respiratory illnesses and scheduled surveillance visits (p<0.001, chi-square) in older children. The prevalence of neutralizing antibodies to RV-A or RV-C types was low (5%-27%) at age 2 years, but by age 16, RV-C seropositivity was more prevalent (78% vs. 18% for RV-A, p<0.0001). In the pooled analysis, the RV-C to RV-A detection ratio during illnesses was significantly related to age (p<0.0001), CDHR3 genotype (p<0.05), and wheezing illnesses (p<0.05). Furthermore, certain RV types (e.g., C2, C11, A78, A12) were consistently more virulent and prevalent over time.
Rhinovirus C (RV-C) can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe wheezing.
To identify how age and other individual-level factors are associated with susceptibility to RV-C illnesses.
Kokoelmat
- Rinnakkaistallenteet [19207]