Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells

Pihlaja R; Takkinen J; Eskola O; Vasara J; Lopez-Picon FR; Haaparanta-Solin M; Rinne JO
Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells

Pihlaja R
Takkinen J
Eskola O
Vasara J
Lopez-Picon FR
Haaparanta-Solin M
Rinne JO
Katso/Avaa
Lataukset: 

BIOMED CENTRAL LTD
doi:10.1186/s12974-015-0305-9
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042715441
Tiivistelmä


Conclusions: JZL184 decreased the proinflammatory reactions of microglia and reduced the total A beta burden and its precursors in the APdE9 mouse model. It also reduced the proinflammatory responses of microglia and astrocytes isolated from adult mice.

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