Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells

Lopez-Picon FR; Vasara J; Rinne JO; Haaparanta-Solin M; Eskola O; Pihlaja R; Takkinen J
Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells

Lopez-Picon FR
Vasara J
Rinne JO
Haaparanta-Solin M
Eskola O
Pihlaja R
Takkinen J
Katso/Avaa
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BIOMED CENTRAL LTD
doi:10.1186/s12974-015-0305-9
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042715441
Tiivistelmä


Conclusions: JZL184 decreased the proinflammatory reactions of microglia and reduced the total A beta burden and its precursors in the APdE9 mouse model. It also reduced the proinflammatory responses of microglia and astrocytes isolated from adult mice.

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