Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells
Lopez-Picon FR; Vasara J; Rinne JO; Haaparanta-Solin M; Eskola O; Pihlaja R; Takkinen J
Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells
Lopez-Picon FR
Vasara J
Rinne JO
Haaparanta-Solin M
Eskola O
Pihlaja R
Takkinen J
BIOMED CENTRAL LTD
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042715441
https://urn.fi/URN:NBN:fi-fe2021042715441
Tiivistelmä
Conclusions: JZL184 decreased the proinflammatory reactions of microglia and reduced the total A beta burden and its precursors in the APdE9 mouse model. It also reduced the proinflammatory responses of microglia and astrocytes isolated from adult mice.
Kokoelmat
- Rinnakkaistallenteet [19207]