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Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations

Reynolds CM; Galante L; Lagstrom H; Cameron-Smith D; Milan AM; Vickers MH; Pundir S; Rautava S

dc.contributor.authorReynolds CM
dc.contributor.authorGalante L
dc.contributor.authorLagstrom H
dc.contributor.authorCameron-Smith D
dc.contributor.authorMilan AM
dc.contributor.authorVickers MH
dc.contributor.authorPundir S
dc.contributor.authorRautava S
dc.date.accessioned2022-10-28T12:34:47Z
dc.date.available2022-10-28T12:34:47Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/160553
dc.description.abstractWhile human milk composition is characterised by marked dynamicity, we are far from having a clear picture of what factors drive this variation. Hormones in human milk are known to vary according to specific maternal phenotypes, but limited evidence shows the infant also has a role in determining milk composition. The present study aimed to investigate the interplay between maternal and infant characteristics in relation to human milk hormonal profile. In total, 501 human milk samples from mothers recruited in the Finnish STEPS cohort study (Steps to the healthy development) were analysed. Pre-pregnancy and pregnancy maternal data, socioeconomic status and infant characteristics at birth were collated. Leptin, adiponectin, insulin-like growth factor-1 and cyclic Glycine-Proline in milk were measured. Multivariate analysis of variance (MANOVA) and linear regression were utilised for statistical analysis. Sex-specific interactions with maternal factors were observed, as the infant sex mediated associations between gestational diabetes and milk adiponectin (p = 0.031), birth-mode and total protein (p = 0.003), maternal education and insulin-like growth factor-1: cyclic Glycine-Proline ratio (p = 0.035). Our results suggest that changes in human milk composition are associated with interactions between maternal and infant characteristics and pathophysiological factors. Future work should expand on these findings and further explore the link between hormonal profiles in human milk and infant outcomes.
dc.language.isoen
dc.publisherMDPI
dc.titleSexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations
dc.identifier.urlhttps://doi.org/10.3390/nu12010152
dc.identifier.urnURN:NBN:fi-fe2021042825295
dc.relation.volume12
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organizationfi=lastentautioppi|en=Paediatrics and Adolescent Medicine|
dc.contributor.organizationfi=kansanterveystiede|en=Public Health|
dc.contributor.organization-code2607307
dc.contributor.organization-code2607313
dc.converis.publication-id46671990
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/46671990
dc.identifier.jour-issn2072-6643
dc.okm.affiliatedauthorLagström, Hanna
dc.okm.affiliatedauthorRautava, Samuli
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3123 Naisten- ja lastentauditfi_FI
dc.okm.discipline3123 Gynaecology and paediatricsen_GB
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countrySwitzerlanden_GB
dc.publisher.countrySveitsifi_FI
dc.publisher.country-codeCH
dc.relation.articlenumberARTN 152
dc.relation.doi10.3390/nu12010152
dc.relation.ispartofjournalNutrients
dc.relation.issue1
dc.year.issued2020


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