Näytä suppeat kuvailutiedot

Two-Year Change in Blood Pressure Status and Left Ventricular Mass Index in Chinese Children

Zhao Min; Xi Bo; Li Zilin; Duan Yao; Magnussen Costan G.

dc.contributor.authorZhao Min
dc.contributor.authorXi Bo
dc.contributor.authorLi Zilin
dc.contributor.authorDuan Yao
dc.contributor.authorMagnussen Costan G.
dc.date.accessioned2022-10-28T12:34:52Z
dc.date.available2022-10-28T12:34:52Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/160563
dc.description.abstract<p>Background: Elevated blood pressure (BP) is associated with target organ damage, such as left ventricular hypertrophy (LVH), in childhood. However, it is unclear if children who resolve elevated BP have reduced levels of left ventricular mass index (LVMI). This study aimed to examine the association between change in BP status over 2 years and LVMI among Chinese children. <br></p><p>Methods: Data were from 1,183 children aged 6-11 years at baseline in 2017 who were followed up in 2019 in the Huantai Childhood Cardiovascular Health Cohort Study. Change in BP status over 2 years from baseline to follow-up was categorized as: persistent normal BP, resolved elevated BP (elevated BP at baseline, normal BP at follow-up), incident elevated BP (normal BP at baseline, elevated BP at follow-up), and persistent elevated BP. Elevated BP status was defined according to national reference standards as systolic or diastolic BP levels >= sex-, age-, and height-specific 95th percentiles. <br></p><p>Results: LVMI levels were lowest in children with persistent normal BP (30.13 g/m(2.7)), higher in those with incident elevated BP (31.27 g/m(2.7)), and highest in those with persistent elevated BP (33.26 g/m(2.7)). However, LVMI levels in those who had resolved elevated BP (30.67 g/m(2.7)) were similar to those with persistent normal BP. In the fully adjusted model, compared with children with persistent normal BP, those with persistent elevated BP and incident elevated BP had higher LVMI at follow-up (ss = 3.131, p < 0.001; ss = 1.143, p = 0.041, respectively). In contrast, those who had resolved elevated BP did not have a significantly higher LVMI (ss = 0.545, p = 0.194) than those with persistent normal BP. <br></p><p>Conclusion: Developing or maintaining elevated BP over a 2-year period in childhood associated with higher levels of LVMI, but those able to resolve their elevated BP status over the same period had LVMI levels that were similar with those who had normal BP at both time points. Thus, it is important to identify children with elevated BP at early time and to take effective measures to lower their BP levels, thereby reducing high LVMI levels and related cardiovascular diseases in the future.<br></p>
dc.language.isoen
dc.publisherFRONTIERS MEDIA SA
dc.titleTwo-Year Change in Blood Pressure Status and Left Ventricular Mass Index in Chinese Children
dc.identifier.urnURN:NBN:fi-fe2021100750228
dc.relation.volume8
dc.contributor.organizationfi=väestötutkimuskeskus|en=Centre for Population Health Research (POP Centre)|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organizationfi=sydäntutkimuskeskus|en=Research Centre of Applied and Preventive Cardiovascular Medicine (CAPC)|
dc.contributor.organization-code2607004
dc.contributor.organization-code2607008
dc.converis.publication-id67283086
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/67283086
dc.identifier.eissn2296-858X
dc.identifier.jour-issn2296-858X
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorMagnussen, Costan
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.discipline3123 Gynaecology and paediatricsen_GB
dc.okm.discipline3123 Naisten- ja lastentauditfi_FI
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countrySveitsifi_FI
dc.publisher.countrySwitzerlanden_GB
dc.publisher.country-codeCH
dc.relation.doi10.3389/fmed.2021.708044
dc.relation.ispartofjournalFrontiers in Medicine
dc.year.issued2021


Aineistoon kuuluvat tiedostot

Thumbnail

Aineisto kuuluu seuraaviin kokoelmiin

Näytä suppeat kuvailutiedot