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The effect of experimental lead pollution on DNA methylation in a wild bird population

van Oers Kees; Eeva Tapio; Ruuskanen Suvi; Mäkinen Hannu

The effect of experimental lead pollution on DNA methylation in a wild bird population

van Oers Kees
Eeva Tapio
Ruuskanen Suvi
Mäkinen Hannu
Katso/Avaa
Final draft (1.190Mb)
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TAYLOR & FRANCIS INC
doi:10.1080/15592294.2021.1943863
URI
https://doi.org/10.1080/15592294.2021.1943863
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022021619437
Tiivistelmä
Anthropogenic pollution is known to negatively influence an organism's physiology, behaviour, and fitness. Epigenetic regulation, such as DNA methylation, has been hypothesized as a potential mechanism to mediate such effects, yet studies in wild species are lacking. We first investigated the effects of early-life exposure to the heavy metal lead (Pb) on DNA methylation levels in a wild population of great tits (Parus major), by experimentally exposing nestlings to Pb at environmentally relevant levels. Secondly, we compared nestling DNA methylation from a population exposed to long-term heavy metal pollution (close to a copper smelter), where birds suffer from pollution-related decrease in food quality, and a control population. For both comparisons, the analysis of about one million CpGs covering most of the annotated genes revealed that pollution-related changes in DNA methylation were not genome wide, but enriched for genes underlying developmental processes. However, the results were not consistent when using binomial or beta binomial regression highlighting the difficulty of modelling variance in CpGs. Our study indicates that post-natal anthropogenic heavy metal exposure can affect methylation levels of development related genes in a wild bird population.
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