PASI: A novel pathway method to identify delicate group effects
Aidan J. McGlinchey; Laura L. Elo; Maria K. Jaakkola; Riku Klen
PASI: A novel pathway method to identify delicate group effects
Aidan J. McGlinchey
Laura L. Elo
Maria K. Jaakkola
Riku Klen
PUBLIC LIBRARY SCIENCE
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042719423
https://urn.fi/URN:NBN:fi-fe2021042719423
Tiivistelmä
Pathway analysis is a common approach in diverse biomedical studies, yet the currently-available pathway tools do not typically support the increasingly popular personalized analyses. Another weakness of the currently-available pathway methods is their inability to handle challenging data with only modest group-based effects compared to natural individual variation. In an effort to address these issues, this study presents a novel pathway method PASI (Pathway Analysis for Sample-level Information) and demonstrates its performance on complex diseases with different levels of group-based differences in gene expression. PASI is freely available as an R package.
Kokoelmat
- Rinnakkaistallenteet [19207]