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Long-Lasting T Cell Responses in BNT162b2 COVID-19 mRNA Vaccinees and COVID-19 Convalescent Patients

Kakkola Laura; Teräsjärvi Johanna; Liedes Oona.; He Qiushui; Ivaska Lauri; Tähtinen Paula A.; Hänninen Arno; Melin Merit; Julkunen Ilkka; Oksi Jarmo; Kantele Anu; Hurme Antti; Heroum Jemna; Vuorinen Tytti; Vara Saimi; Pöysti Sakari; Lempainen Johanna; Jalkanen Pinja

dc.contributor.authorKakkola Laura
dc.contributor.authorTeräsjärvi Johanna
dc.contributor.authorLiedes Oona.
dc.contributor.authorHe Qiushui
dc.contributor.authorIvaska Lauri
dc.contributor.authorTähtinen Paula A.
dc.contributor.authorHänninen Arno
dc.contributor.authorMelin Merit
dc.contributor.authorJulkunen Ilkka
dc.contributor.authorOksi Jarmo
dc.contributor.authorKantele Anu
dc.contributor.authorHurme Antti
dc.contributor.authorHeroum Jemna
dc.contributor.authorVuorinen Tytti
dc.contributor.authorVara Saimi
dc.contributor.authorPöysti Sakari
dc.contributor.authorLempainen Johanna
dc.contributor.authorJalkanen Pinja
dc.date.accessioned2022-10-28T12:38:01Z
dc.date.available2022-10-28T12:38:01Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/160931
dc.description.abstract<p>The emergence of novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made it more difficult to prevent the virus from spreading despite available vaccines. Reports of breakthrough infections and decreased capacity of antibodies to neutralize variants raise the question whether current vaccines can still protect against COVID-19 disease. We studied the dynamics and persistence of T cell responses using activation induced marker (AIM) assay and Th1 type cytokine production in peripheral blood mononuclear cells obtained from BNT162b2 COVID-19 mRNA vaccinated health care workers and COVID-19 patients. We demonstrate that equally high T cell responses following vaccination and infection persist at least for 6 months against Alpha, Beta, Gamma, and Delta variants despite the decline in antibody levels.<br></p>
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.titleLong-Lasting T Cell Responses in BNT162b2 COVID-19 mRNA Vaccinees and COVID-19 Convalescent Patients
dc.identifier.urlhttps://doi.org/10.3389/fimmu.2022.869990
dc.identifier.urnURN:NBN:fi-fe2022081154157
dc.relation.volume13
dc.contributor.organizationfi=sisätautioppi|en=Internal Medicine|
dc.contributor.organizationfi=InFLAMES lippulaiva, tutkimus|en=InFLAMES Flagship, research|
dc.contributor.organizationfi=lastentautioppi|en=Paediatrics and Adolescent Medicine|
dc.contributor.organizationfi=infektiotautioppi|en=Infectious Diseases|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organizationfi=biolääketieteen laitos, yhteiset|en=Institute of Biomedicine|
dc.contributor.organization-code2607051
dc.contributor.organization-code2607318
dc.contributor.organization-code2607313
dc.contributor.organization-code2607100
dc.contributor.organization-code2607306
dc.converis.publication-id175680302
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/175680302
dc.identifier.eissn1664-3224
dc.identifier.jour-issn1664-3224
dc.okm.affiliatedauthorPöysti, Sakari
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorTeräsjärvi, Johanna
dc.okm.affiliatedauthorHänninen, Arno
dc.okm.affiliatedauthorLempainen, Johanna
dc.okm.affiliatedauthorHurme, Antti
dc.okm.affiliatedauthorJalkanen, Pinja
dc.okm.affiliatedauthorKakkola, Laura
dc.okm.affiliatedauthorOksi, Jarmo
dc.okm.affiliatedauthorVuorinen, Tytti
dc.okm.affiliatedauthorJulkunen, Ilkka
dc.okm.affiliatedauthorTähtinen, Paula
dc.okm.affiliatedauthorIvaska, Lauri
dc.okm.affiliatedauthorHeroum, Jemna
dc.okm.affiliatedauthorHe, Qiushui
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countrySwitzerlanden_GB
dc.publisher.countrySveitsifi_FI
dc.publisher.country-codeCH
dc.relation.articlenumber869990
dc.relation.doi10.3389/fimmu.2022.869990
dc.relation.ispartofjournalFrontiers in Immunology
dc.year.issued2022


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