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Oxytocin receptor genotype moderates the association between maternal prenatal stress and infant early self-regulation

Nolvi Saara; Karlsson Hasse; Kajanoja Jani; Karlsson Linnea; Paunio Tiina; Kantojärvi Katri

Oxytocin receptor genotype moderates the association between maternal prenatal stress and infant early self-regulation

Nolvi Saara
Karlsson Hasse
Kajanoja Jani
Karlsson Linnea
Paunio Tiina
Kantojärvi Katri
Katso/Avaa
1-s2.0-S0306453022000105-main.pdf (897.5Kb)
Lataukset: 

Elsevier
doi:10.1016/j.psyneuen.2022.105669
URI
https://doi.org/10.1016/j.psyneuen.2022.105669
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022081154205
Tiivistelmä

Introduction

Maternal prenatal stress may have long-term adverse consequences for child development. Accumulating evidence shows that the oxytocin-receptor genotype may play a role in differential susceptibility to early-life adversity, but no studies have examined whether this moderation extends to the prenatal stress exposures.

Methods

In the FinnBrain Birth Cohort Study, a sample of 1173 mother-child dyads were examined. We studied the possible moderating effect of the cumulative effect of infant oxytocin-receptor risk genotypes (rs53576GG and rs2254298A) in the association between maternal prenatal stress, and infant negative reactivity and emerging self-regulation at 6 months of age.

Results

The number of OTr risk genotypes moderated the association between maternal prenatal anxiety and infant self-regulation, implying a cumulative effect of genotype, although effects sizes were small. In infants with two risk genotypes, a negative association between prenatal anxiety and self-regulation was observed, whereas in infants with one or no risk genotypes, the association between maternal prenatal anxiety and temperament was non-significant.

Conclusion

Oxytocin-receptor genotype may moderate the association of maternal stress during pregnancy and child social-emotional development. Possible mechanisms for this moderation effect are discussed. Further studies with a more comprehensive polygenic approach are needed to confirm these results.

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  • Rinnakkaistallenteet [19207]

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