Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations
Gabi Kastenmüller; Olli Raitakari; Eva Rodríguez; Barbara Thorand; Peter Würtz; Juan Pedro-Botet; Andres Metspalu; Julio Pascual; Christian Gieger; Clara Barrios; Christa Meisinger; Sol Otero; Tim D. Spector; Mika Ala-Korpela; Mika Kähönen; Toomas Haller; Jonas Zierer; Terho Lehtimäki; Melanie Waldenberger; Cristina Menni
Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations
Gabi Kastenmüller
Olli Raitakari
Eva Rodríguez
Barbara Thorand
Peter Würtz
Juan Pedro-Botet
Andres Metspalu
Julio Pascual
Christian Gieger
Clara Barrios
Christa Meisinger
Sol Otero
Tim D. Spector
Mika Ala-Korpela
Mika Kähönen
Toomas Haller
Jonas Zierer
Terho Lehtimäki
Melanie Waldenberger
Cristina Menni
NATURE PUBLISHING GROUP
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042720051
https://urn.fi/URN:NBN:fi-fe2021042720051
Tiivistelmä
Using targeted NMR spectroscopy of 227 fasting serum metabolic traits, we searched for novel metabolic signatures of renal function in 926 type 2 diabetics (T2D) and 4838 non-diabetic individuals from four independent cohorts. We furthermore investigated longitudinal changes of metabolic measures and renal function and associations with other T2D microvascular complications. 142 traits correlated with glomerular filtration rate (eGFR) after adjusting for confounders and multiple testing: 59 in diabetics, 109 in non-diabetics with 26 overlapping. The amino acids glycine and phenylalanine and the energy metabolites citrate and glycerol were negatively associated with eGFR in all the cohorts, while alanine, valine and pyruvate depicted opposite association in diabetics (positive) and nondiabetics (negative). Moreover, in all cohorts, the triglyceride content of different lipoprotein subclasses showed a negative association with eGFR, while cholesterol, cholesterol esters (CE), and phospholipids in HDL were associated with better renal function. In contrast, phospholipids and CEs in LDL showed positive associations with eGFR only in T2D, while phospholipid content in HDL was positively associated with eGFR both cross-sectionally and longitudinally only in non-diabetics. In conclusion, we provide a wide list of kidney function-associated metabolic traits and identified novel metabolic differences between diabetic and non-diabetic kidney disease.
Kokoelmat
- Rinnakkaistallenteet [19207]