Molecular Mechanisms of Membrane Deformation by I-BAR Domain Proteins

Lappalainen P; Laurinmaki P; Zhao HX; Saarikangas J; Butcher SJ; Mattila PK; Kinnunen PKJ; Pykalainen A
Molecular Mechanisms of Membrane Deformation by I-BAR Domain Proteins

Lappalainen P
Laurinmaki P
Zhao HX
Saarikangas J
Butcher SJ
Mattila PK
Kinnunen PKJ
Pykalainen A
Katso/Avaa
Lataukset: 

CELL PRESS
doi:10.1016/j.cub.2008.12.029
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042714244
Tiivistelmä
Conclusions: These data define I-BAR domain as a functional member of the BAR domain superfamily and unravel the mechanisms by which I-BAR domains deform membranes to induce filopodia in cells. Furthermore, our work reveals unexpected divergence in the mechanisms by which evolutionarily distinct groups of I-BAR domains interact with PI(4,5)P(2)-rich membranes.
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