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Interactive visual analysis of drug-target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing

Ianevski Aleksandr; Aittokallio Tero; Wennerberg Krister; Vähä-Koskela Markus; Tanoli Ziaurrehman; Alam Zaid

dc.contributor.authorIanevski Aleksandr
dc.contributor.authorAittokallio Tero
dc.contributor.authorWennerberg Krister
dc.contributor.authorVähä-Koskela Markus
dc.contributor.authorTanoli Ziaurrehman
dc.contributor.authorAlam Zaid
dc.date.accessioned2022-10-28T13:08:11Z
dc.date.available2022-10-28T13:08:11Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/163045
dc.description.abstractKnowledge of the full target space of drugs (or drug-like compounds) provides important insights into the potential therapeutic use of the agents to modulate or avoid their various on- and off-targets in drug discovery and precision medicine. However, there is a lack of consolidated databases and associated data exploration tools that allow for systematic profiling of drug target-binding potencies of both approved and investigational agents using a network-centric approach. We recently initiated a community-driven platform, Drug Target Commons (DTC), which is an open-data crowdsourcing platform designed to improve the management, reproducibility and extended use of compound-target bioactivity data for drug discovery and repurposing, as well as target identification applications. In this work, we demonstrate an integrated use of the rich bioactivity data from DTC and related drug databases using Drug Target Profiler (DTP), an open-source software and web tool for interactive exploration of drug-target interaction networks. DTP was designed for network-centric modeling of mode-of-action of multi-targeting anticancer compounds, especially for precision oncology applications. DTP enables users to construct an interaction network based on integrated bioactivity data across selected chemical compounds and their protein targets, further customizable using various visualization and filtering options, as well as cross-links to several drug and protein databases to provide comprehensive information of the network nodes and interactions. We demonstrate here the operation of the DTP tool and its unique features by several use cases related to both drug discovery and drug repurposing applications, using examples of anticancer drugs with shared target profiles. DTP is freely accessible at http://drugtargetprofiler.fimm.fi/.
dc.language.isoen
dc.publisherOXFORD UNIV PRESS
dc.titleInteractive visual analysis of drug-target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing
dc.identifier.urlhttps://academic.oup.com/bib/advance-article/doi/10.1093/bib/bby119/5232987
dc.identifier.urnURN:NBN:fi-fe2021042821378
dc.relation.volume21
dc.contributor.organizationfi=matematiikka|en=Mathematics|
dc.contributor.organization-code2606101
dc.converis.publication-id39175522
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/39175522
dc.format.pagerange220
dc.format.pagerange211
dc.identifier.eissn1477-4054
dc.identifier.jour-issn1467-5463
dc.okm.affiliatedauthorAittokallio, Tero
dc.okm.discipline317 Farmasiafi_FI
dc.okm.discipline317 Pharmacyen_GB
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA2 Review article
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.countryBritanniafi_FI
dc.publisher.country-codeGB
dc.relation.doi10.1093/bib/bby119
dc.relation.ispartofjournalBriefings in Bioinformatics
dc.relation.issue1
dc.year.issued2020


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