Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library
Otto S; Colomb-Delsuc M; Nowak P; Li JW
Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library
Otto S
Colomb-Delsuc M
Nowak P
Li JW
AMER CHEMICAL SOC
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042717939
https://urn.fi/URN:NBN:fi-fe2021042717939
Tiivistelmä
Self-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication of this molecule. However, if the concentration of the potential replicator in the DCL fails to exceed its critical aggregation concentration (CAC), then self-replication will not occur. We now show how addition of a template can raise the concentration of a library member-template complex beyond its CAC, leading to the onset of self-replication. Once in existence, the replicator aggregates promote further replication also in the absence of the template that induced the initial emergence of the replicator.
Kokoelmat
- Rinnakkaistallenteet [19207]