Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
Xia R; Seshadri S; Scott RJ; Smith AV; Teumer A; Loeffler M; Bennett DA; Tuominen S; Thalamuthu A; Mather KA; Painter J; Luck T; De Jager PL; Ulrich W; Lee T; Lahti J; Trollor J; Schraut KE; Smith JA; Reppermund S; van der Lee SJ; Palotie A; Schofield PW; Fornage M; Campbell A; Davies G; Goldman AL; Turner ST; Kardia SLR; Starr JM; Li S; Mosley TH; Trompet S; Fohner AE; Grodstein F; Ikram MA; Psaty BM; Yu L; Weinberger DR; Nalls MA; Riedel-Heller SG; Joshi PK; Hayward C; Rose RJ; Satizabal CL; Armstrong NJ; Fitzpatrick AL; Wagner M; Medland S; Cox SR; Beiser A; Volker U; Lencz T; Weir DR; Bressler J; Wilson JF; Stott DJ; Bey K; Wright MJ; Villringer A; Oldmeadow C; Mattay VS; Zhao W; Kwok JB; Gerring Z; Mirza SS; Sachdev PS; Simonsick E; Vuoksimaa E; Loukola A; Launer LJ; Lam M; Deary IJ; Yaffe K; Faul JD; Pergola G; Ahmad S; Kleineidam L; Yang Q; Holliday EG; Corley J; Risacher SL; Eriksson JG; Kaprio J; Derks EM; Wittfeld K; Chen Q; Attia J; Boerwinkle E; Raikkonen K; Bis JC; Scholz M; Jukema JW; Nho K; Brodaty H; Pattie A; Wilson RS; Grabe HJ; Karell P; Surakka I; Ames D; Scherer M; Ramirez A; Gudnason V; Schofield PR; Amin N; Sadashivaiah V; O'Donnell A; Saykin AJ; van Duijn CM; Zare H; Ridker PM; Sidney S; Campbell H; Simino J; Debette S; Chasman DI; Leber M; Marioni RE; Kajantie E; Kochan NA; Knol MJ; Ford I
Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning
SPRINGER NATURE
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022091358909
https://urn.fi/URN:NBN:fi-fe2022091358909
Tiivistelmä
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
Kokoelmat
- Rinnakkaistallenteet [19207]