The human diabetes proteome project (HDPP): The 2014 update
Baek K.-H; Mulder H; Bergsten P; Wiederkehr A; Tiss A; Priego-Capote F; Finamore F; Barba De La Rosa A; Xenarios I; Snyder M; Goo Y-A; Sechi S; Dayon L; Goodlett D; Johnson J.D; Konvalinka A; Moulder R; Kussmann M; Cantley J; Schvartz D; Fontana P; Sanchez J-C; Gaudet P
https://urn.fi/URN:NBN:fi-fe2021042714866
Tiivistelmä
Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.
Kokoelmat
- Rinnakkaistallenteet [19207]