Synthesis of an Azide- and Tetrazine-Functionalized [60]Fullerene and Its Controlled Decoration with Biomolecules
Yliperttula Marjo; Ali Aliaa; Valle-Delgado Juan José; Virta Pasi; Äärelä Antti; Gulumkar Vijay; Österberg Monika; Tähtinen Ville; Rahkila Jani
Synthesis of an Azide- and Tetrazine-Functionalized [60]Fullerene and Its Controlled Decoration with Biomolecules
Yliperttula Marjo
Ali Aliaa
Valle-Delgado Juan José
Virta Pasi
Äärelä Antti
Gulumkar Vijay
Österberg Monika
Tähtinen Ville
Rahkila Jani
AMER CHEMICAL SOC
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022081154520
https://urn.fi/URN:NBN:fi-fe2022081154520
Tiivistelmä
Bingel cyclopropanation between Buckminster fullerene and a heteroarmed malonate was utilized to produce a hexakis-functionalized C60 core, with azide and tetrazine units. This orthogonally bifunctional C60 scaffold can be selectively one-pot functionalized by two pericyclic click reactions, that is, inverse electron-demand Diels-Alder and azide-alkyne cycloaddition, which with appropriate ligands (monosaccharides, a peptide and oligonucleotides tested) allows one to control the assembly of heteroantennary bioconjugates.
Kokoelmat
- Rinnakkaistallenteet [19207]