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Lifetime risk assessment in cholesterol management among hypertensive patients: observational cross-sectional study based on electronic health record data

Pekka Mäntyselkä; Teemu Niiranen; Aapo Tahkola; Päivi Korhonen; Hannu Kautiainen

dc.contributor.authorPekka Mäntyselkä
dc.contributor.authorTeemu Niiranen
dc.contributor.authorAapo Tahkola
dc.contributor.authorPäivi Korhonen
dc.contributor.authorHannu Kautiainen
dc.date.accessioned2022-10-28T13:16:36Z
dc.date.available2022-10-28T13:16:36Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/164067
dc.description.abstract<div>Background: In hypertensive patients, reducing plasma low-density lipoprotein cholesterol level (LDL-C) is one of the main interventions for preventing chronic cardiovascular diseases (CVD). However, LDL-C control remains generally insufficient, also in patients with hypertension. We analyzed Electronic Health Record (EHR) data of 7117 hypertensive patients to find the most potential age and sex subgroups in greatest need for improvement in real life dyslipidemia treatment. Taking into account the current discussion on lifetime CVD risk, we focused on the age dependence in LDL-C control. <br /></div><div><br /></div><div>Methods: In this observational cross-sectional study, based on routine electronic health record (EHR) data, we investigated LDL-C control of hypertensive, non-diabetic patients without renal dysfunction or CVD, aged 30 years or more in Finnish primary care setting. <br /></div><div><br /></div><div>Results: More than half (54% of women and 53% of men) of untreated patients did not meet the LDL-C target of < 3 mmol/l and one third (35% of women and 33% of men) of patients did not reach the target even with the lipid-lowering medication (LLM). Furthermore, higher age was strongly associated with better LDL-C control (p < 0.001) and lower LDL-C level (p < 0.001) in individuals with and without LLM. Higher age was also strongly associated with LLM prescription (p < 0.001). In total, about half of the patients were on LLM (53% of women and 51% of men). <br /></div><div><br /></div><div>Conclusions: Our findings indicate that dyslipidemia treatment among Finnish primary care hypertensive patients is generally insufficient, particularly in younger age groups who might benefit the most from CVD risk reduction over time. Clinicians should probably rely more on the lifetime risk of CVD, especially when treating working age hypertensive patients.</div>
dc.language.isoen
dc.publisherBMC
dc.titleLifetime risk assessment in cholesterol management among hypertensive patients: observational cross-sectional study based on electronic health record data
dc.identifier.urnURN:NBN:fi-fe2021042822169
dc.relation.volume21
dc.contributor.organizationfi=yleislääketiede|en=General Practice|
dc.contributor.organizationfi=sisätautioppi|en=Internal Medicine|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organization-code2607318
dc.contributor.organization-code2607328
dc.converis.publication-id47762541
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/47762541
dc.identifier.eissn1471-2296
dc.identifier.jour-issn1471-2296
dc.okm.affiliatedauthorNiiranen, Teemu
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorKorhonen, Päivi
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.countryBritanniafi_FI
dc.publisher.country-codeGB
dc.relation.articlenumberARTN 62
dc.relation.doi10.1186/s12875-020-01138-5
dc.relation.ispartofjournalBMC Family Practice
dc.relation.issue1
dc.year.issued2020


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