Defining new clinically derived criteria for high disease activity in non-systemic juvenile idiopathic arthritis: a Finnish multicentre study
Maria Backström; Pirjo Tynjälä; Helena Lehto; Sirja Sard; Minna-Maija Grönlund; Heikki Ylijoki; Eliisa Löyttyniemi; Paula Keskitalo; Silke Witter; Heini Pohjankoski; Johanna Kärki; Paula Vähäsalo; Maiju Hietanen; Anne Putto-Laurila; Kristiina Aalto
https://urn.fi/URN:NBN:fi-fe2021042822181
Tiivistelmä
To redefine criteria for high disease activity (HDA) in JIA, to establish HDA cut-off values for the 10-joint Juvenile Arthritis Disease Activity Score (JADAS10) and clinical JADAS10 (cJADAS10) and to describe the distribution of patients’ disease activity levels based on the JADAS cut-off values in the literature.
Data on 305 treatment-naïve JIA patients were collected from nine paediatric units treating JIA. The median parameters of the JADAS were proposed to be the clinical criteria for HDA. The cut-off values were assessed by using two receiver operating characteristics curve–based methods. The patients were divided into disease activity levels based on currently used JADAS cut-off values.
We proposed new criteria for HDA. At least three of the following criteria must be satisfied in both disease courses: in oligoarthritis, two or more active joints, ESR above normal, physician global assessment (PGA) of disease activity ≥2 and parent/patient global assessment (PtGA) of well-being ≥2; in polyarthritis, six or more active joints, ESR above normal, PGA of overall disease activity ≥4 and PtGA of well-being ≥2. The HDA cut-off values for JADAS10 (cJADAS) were ≥6.7 (6.7) for oligoarticular and ≥15.3 (14.1) for polyarticular disease. The distribution of the disease activity levels based on the JADAS cut-off values in the literature varied markedly based on which cut-offs were used.
New clinically derived criteria for HDA in JIA and both JADAS and cJADAS cut-off values for HDA were proposed.
Kokoelmat
- Rinnakkaistallenteet [19207]