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Triglycerides and low HDL cholesterol predict coronary heart disease risk in patients with stable angina

Campolo Jonica; Clemente Alberto; Sampietro Tiziana; Scholte Arthur; Liga Riccardo; Rocchiccioli Silvia; Smit Jeff M.; Neglia Danilo; EVINCI; SMARTool; Ragusa Rosetta; Clerico Aldo; Parodi Oberdan; Pelosi Gualtiero; Caselli Chiara; Knuuti Juhani; De Caterina Raffaele; El Mahdiui Mohammed

Triglycerides and low HDL cholesterol predict coronary heart disease risk in patients with stable angina

Campolo Jonica
Clemente Alberto
Sampietro Tiziana
Scholte Arthur
Liga Riccardo
Rocchiccioli Silvia
Smit Jeff M.
Neglia Danilo; EVINCI; SMARTool
Ragusa Rosetta
Clerico Aldo
Parodi Oberdan
Pelosi Gualtiero
Caselli Chiara
Knuuti Juhani
De Caterina Raffaele
El Mahdiui Mohammed
Katso/Avaa
Publisher´s pdf (1.454Mb)
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NATURE PORTFOLIO
doi:10.1038/s41598-021-00020-3
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022012710765
Tiivistelmä

We assessed whether high triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, expressed by an increased TG/HDL-C ratio, predict coronary atherosclerotic disease (CAD) outcomes in patients with stable angina. We studied 355 patients (60 ± 9 years, 211 males) with stable angina who underwent coronary computed tomography angiography (CTA), were managed clinically and followed for 4.5 ± 0.9 years. The primary composite outcome was all-cause mortality and non-fatal myocardial infarction. At baseline, the proportion of males, patients with metabolic syndrome, diabetes and obstructive CAD increased across TG/HDL-C ratio quartiles, together with markers of insulin resistance, hepatic and adipose tissue dysfunction and myocardial damage, with no difference in total cholesterol or LDL-C. At follow-up, the global CTA risk score (HR 1.06, 95% confidence interval (CI) 1.03-1.09, P = 0.001) and the IV quartile of the TG/HDL-C ratio (HR 2.85, 95% CI 1.30-6.26, P < 0.01) were the only independent predictors of the primary outcome. The TG/HDL-C ratio and the CTA risk score progressed over time despite increased use of lipid-lowering drugs and reduction in LDL-C. In patients with stable angina, high TG and low HDL-C levels are associated with CAD related outcomes independently of LDL-C and treatments.

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