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Genome-Wide Changes in Genetic Diversity in a Population of Myotis lucifugus Affected by White-Nose Syndrome

Anna S. Blomberg; Samantha Hoff; Megan E. Vodzak; Thomas M. Lilley; Brent J. Sewall; Allen Kurta; Kenneth A. Field; Steve Paterson; DeeAnn M. Reeder; Carl J. Herzog; Gregory G. Turner; Ian W. Wilson

dc.contributor.authorAnna S. Blomberg
dc.contributor.authorSamantha Hoff
dc.contributor.authorMegan E. Vodzak
dc.contributor.authorThomas M. Lilley
dc.contributor.authorBrent J. Sewall
dc.contributor.authorAllen Kurta
dc.contributor.authorKenneth A. Field
dc.contributor.authorSteve Paterson
dc.contributor.authorDeeAnn M. Reeder
dc.contributor.authorCarl J. Herzog
dc.contributor.authorGregory G. Turner
dc.contributor.authorIan W. Wilson
dc.date.accessioned2022-10-28T13:20:39Z
dc.date.available2022-10-28T13:20:39Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/164501
dc.description.abstractNovel pathogens can cause massive declines in populations, and even extirpation of hosts. But disease can also act as a selective pressure on survivors, driving the evolution of resistance or tolerance. Bat white-nose syndrome (WNS) is a rapidly spreading wildlife disease in North America. The fungus causing the disease invades skin tissues of hibernating bats, resulting in disruption of hibernation behavior, premature energy depletion, and subsequent death. We used whole-genome sequencing to investigate changes in allele frequencies within a population of Myotis lucifugus in eastern North America to search for genetic resistance to WNS. Our results show low F-ST values within the population across time, i.e., prior to WNS (Pre-WNS) compared to the population that has survived WNS (Post-WNS). However, when dividing the population with a geographical cut-off between the states of Pennsylvania and New York, a sharp increase in values on scaffold GL429776 is evident in the Post-WNS samples. Genes present in the diverged area are associated with thermoregulation and promotion of brown fat production. Thus, although WNS may not have subjected the entire M. lucifugus population to selective pressure, it may have selected for specific alleles in Pennsylvania through decreased gene flow within the population. However, the persistence of remnant sub-populations in the aftermath of WNS is likely due to multiple factors in bat life history.
dc.language.isoen
dc.publisherGENETICS SOCIETY AMERICA
dc.titleGenome-Wide Changes in Genetic Diversity in a Population of Myotis lucifugus Affected by White-Nose Syndrome
dc.identifier.urlhttps://www.g3journal.org/content/10/6/2007
dc.identifier.urnURN:NBN:fi-fe2021042826542
dc.relation.volume10
dc.contributor.organizationfi=biologian laitoksen yhteiset|en=Department of Biology|
dc.contributor.organization-code2606400
dc.converis.publication-id48477418
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/48477418
dc.format.pagerange2020
dc.format.pagerange2007
dc.identifier.eissn2160-1836
dc.identifier.jour-issn2160-1836
dc.okm.affiliatedauthorBlomberg, Anna
dc.okm.discipline1184 Genetics, developmental biology, physiologyen_GB
dc.okm.discipline1184 Genetiikka, kehitysbiologia, fysiologiafi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.relation.doi10.1534/g3.119.400966
dc.relation.ispartofjournalG3: genes, genomes, genetics
dc.relation.issue6
dc.year.issued2020


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