Blockage of Collagen Binding to Integrin alpha2beta1: Structure-activity Relationships of Protein-protein Interaction Inhibitors
Koivunen JT; Marjamäki A; Pentikäinen OT; Nissinen L; Pihlavisto M; Juhakoski A; Huuskonen J
Blockage of Collagen Binding to Integrin alpha2beta1: Structure-activity Relationships of Protein-protein Interaction Inhibitors
Koivunen JT
Marjamäki A
Pentikäinen OT
Nissinen L
Pihlavisto M
Juhakoski A
Huuskonen J
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042719826
https://urn.fi/URN:NBN:fi-fe2021042719826
Tiivistelmä
The interaction between the alpha2beta1
integrin and collagen plays a crucial role in the development of pathological
conditions, such as thrombus formation and cancer cell metastasis. Accordingly,
the alpha2beta1 integrin is a promising target for the development of new drug
molecules to treat these diseases. Here, we have designed, synthesized, and
measured in vitro a set of novel drug-like compounds that block the protein–protein
interactions between alpha2beta1 integrin and collagen. The obtained
structure–activity relationship reveals the key features that are required for
successful inhibition of this integrin–collagen interaction.
Kokoelmat
- Rinnakkaistallenteet [19207]