dc.contributor.author | Auranen Kari | |
dc.contributor.author | Peltonen Sirkku | |
dc.contributor.author | Valtanen Mikko | |
dc.contributor.author | Peltonen Juha | |
dc.contributor.author | Rinne Juha O | |
dc.contributor.author | Kallionpää Roope A | |
dc.contributor.author | Uusitalo Elina | |
dc.date.accessioned | 2022-10-28T13:25:24Z | |
dc.date.available | 2022-10-28T13:25:24Z | |
dc.identifier.uri | https://www.utupub.fi/handle/10024/165075 | |
dc.description.abstract | <p><strong>Purpose: </strong>To determine the risk for dementia in neurofibromatosis type 1 (NF1) using a Finnish nationwide cohort of individuals with NF1, and data from national registries.</p><p><strong>Methods: </strong>A Finnish cohort of 1,349 individuals with confirmed NF1 according to the US National Institutes of Health (NIH) diagnostic criteria was compared with a control cohort of 13,870 individuals matched for age, sex, and area of residence. Dementia-related hospital visits were retrieved from the Finnish Care Register for Health Care using International Classification of Diseases, 10th revision (ICD-10) diagnosis codes G30 and F00-F03. Purchases of antidementia drugs were queried with Anatomical Therapeutic Chemical (ATC) classification code N06D from the drug reimbursement register maintained by the Social Insurance Institution of Finland. The follow-up spanned 1998-2014.</p><p><strong>Results: </strong>Totals of 16 and 165 individuals with at least two dementia-related diagnoses or drug purchases were identified in the NF1 and control cohorts, respectively. The hazard ratio for dementia in NF1 was 1.67 (95% confidence interval [CI] 1.00-2.80, P = 0.050). In an analysis stratified by the type of dementia, the risk for Alzheimer disease was increased in NF1 compared to controls with a hazard ratio of 2.88 (95% CI 1.47-5.66, P = 0.002).</p><p><strong>Conclusion: </strong>Dementia and especially Alzheimer disease are previously unrecognized neurological complications of NF1.</p><p>© 2021. The Author(s).</p> | |
dc.language.iso | en | |
dc.publisher | Nature Publishing Group | |
dc.title | Increased risk for dementia in neurofibromatosis type 1 | |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1098360021051856?via%3Dihub | |
dc.identifier.urn | URN:NBN:fi-fe2021093048476 | |
dc.contributor.organization | fi=tilastotiede|en=Statistics| | |
dc.contributor.organization | fi=kliinisen laitoksen yhteiset|en=Department of Clinical Medicine| | |
dc.contributor.organization | fi=tyks, vsshp|en=tyks, vsshp| | |
dc.contributor.organization | fi=biolääketieteen laitos, yhteiset|en=Institute of Biomedicine| | |
dc.contributor.organization | fi=PET perustoiminta|en=PET Basic Operations| | |
dc.contributor.organization | fi=iho- ja sukupuolitautioppi|en=Dermatology and Venereology| | |
dc.contributor.organization-code | 2607305 | |
dc.contributor.organization-code | 2607100 | |
dc.contributor.organization-code | 2606103 | |
dc.contributor.organization-code | 2609810 | |
dc.contributor.organization-code | 2607300 | |
dc.converis.publication-id | 66369813 | |
dc.converis.url | https://research.utu.fi/converis/portal/Publication/66369813 | |
dc.identifier.eissn | 1530-0366 | |
dc.identifier.jour-issn | 1098-3600 | |
dc.okm.affiliatedauthor | Rinne, Juha | |
dc.okm.affiliatedauthor | Peltonen, Juha | |
dc.okm.affiliatedauthor | Uusitalo, Elina | |
dc.okm.affiliatedauthor | Peltonen, Sirkku | |
dc.okm.affiliatedauthor | Dataimport, tyks, vsshp | |
dc.okm.affiliatedauthor | Valtanen, Mikko | |
dc.okm.affiliatedauthor | Kallionpää, Roope | |
dc.okm.affiliatedauthor | Auranen, Kari | |
dc.okm.discipline | 3121 Internal medicine | en_GB |
dc.okm.discipline | 3124 Neurology and psychiatry | en_GB |
dc.okm.discipline | 3124 Neurologia ja psykiatria | fi_FI |
dc.okm.discipline | 3121 Sisätaudit | fi_FI |
dc.okm.internationalcopublication | international co-publication | |
dc.okm.internationality | International publication | |
dc.okm.type | Journal article | |
dc.publisher.country | Yhdysvallat (USA) | fi_FI |
dc.publisher.country | United States | en_GB |
dc.publisher.country-code | US | |
dc.relation.doi | 10.1038/s41436-021-01261-3 | |
dc.relation.ispartofjournal | Genetics in Medicine | |
dc.year.issued | 2021 | |