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Increased risk for dementia in neurofibromatosis type 1

Auranen Kari; Peltonen Sirkku; Valtanen Mikko; Peltonen Juha; Rinne Juha O; Kallionpää Roope A; Uusitalo Elina

dc.contributor.authorAuranen Kari
dc.contributor.authorPeltonen Sirkku
dc.contributor.authorValtanen Mikko
dc.contributor.authorPeltonen Juha
dc.contributor.authorRinne Juha O
dc.contributor.authorKallionpää Roope A
dc.contributor.authorUusitalo Elina
dc.date.accessioned2022-10-28T13:25:24Z
dc.date.available2022-10-28T13:25:24Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/165075
dc.description.abstract<p><strong>Purpose: </strong>To determine the risk for dementia in neurofibromatosis type 1 (NF1) using a Finnish nationwide cohort of individuals with NF1, and data from national registries.</p><p><strong>Methods: </strong>A Finnish cohort of 1,349 individuals with confirmed NF1 according to the US National Institutes of Health (NIH) diagnostic criteria was compared with a control cohort of 13,870 individuals matched for age, sex, and area of residence. Dementia-related hospital visits were retrieved from the Finnish Care Register for Health Care using International Classification of Diseases, 10th revision (ICD-10) diagnosis codes G30 and F00-F03. Purchases of antidementia drugs were queried with Anatomical Therapeutic Chemical (ATC) classification code N06D from the drug reimbursement register maintained by the Social Insurance Institution of Finland. The follow-up spanned 1998-2014.</p><p><strong>Results: </strong>Totals of 16 and 165 individuals with at least two dementia-related diagnoses or drug purchases were identified in the NF1 and control cohorts, respectively. The hazard ratio for dementia in NF1 was 1.67 (95% confidence interval [CI] 1.00-2.80, P = 0.050). In an analysis stratified by the type of dementia, the risk for Alzheimer disease was increased in NF1 compared to controls with a hazard ratio of 2.88 (95% CI 1.47-5.66, P = 0.002).</p><p><strong>Conclusion: </strong>Dementia and especially Alzheimer disease are previously unrecognized neurological complications of NF1.</p><p>© 2021. The Author(s).</p>
dc.language.isoen
dc.publisherNature Publishing Group
dc.titleIncreased risk for dementia in neurofibromatosis type 1
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1098360021051856?via%3Dihub
dc.identifier.urnURN:NBN:fi-fe2021093048476
dc.contributor.organizationfi=tilastotiede|en=Statistics|
dc.contributor.organizationfi=kliinisen laitoksen yhteiset|en=Department of Clinical Medicine|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organizationfi=biolääketieteen laitos, yhteiset|en=Institute of Biomedicine|
dc.contributor.organizationfi=PET perustoiminta|en=PET Basic Operations|
dc.contributor.organizationfi=iho- ja sukupuolitautioppi|en=Dermatology and Venereology|
dc.contributor.organization-code2607305
dc.contributor.organization-code2607100
dc.contributor.organization-code2606103
dc.contributor.organization-code2609810
dc.contributor.organization-code2607300
dc.converis.publication-id66369813
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/66369813
dc.identifier.eissn1530-0366
dc.identifier.jour-issn1098-3600
dc.okm.affiliatedauthorRinne, Juha
dc.okm.affiliatedauthorPeltonen, Juha
dc.okm.affiliatedauthorUusitalo, Elina
dc.okm.affiliatedauthorPeltonen, Sirkku
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorValtanen, Mikko
dc.okm.affiliatedauthorKallionpää, Roope
dc.okm.affiliatedauthorAuranen, Kari
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.discipline3124 Neurology and psychiatryen_GB
dc.okm.discipline3124 Neurologia ja psykiatriafi_FI
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.countryUnited Statesen_GB
dc.publisher.country-codeUS
dc.relation.doi10.1038/s41436-021-01261-3
dc.relation.ispartofjournalGenetics in Medicine
dc.year.issued2021


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