Job Strain as a Risk Factor for Peripheral Artery Disease: A Multi-Cohort Study
Marianne Borritz; Tuula Oksanen; Tea Lallukka; Archana Singh‐Manoux; Jussi Vahtera; Hermann Burr; Solja T. Nyberg; Jan H. Pejtersen; Constanze Leineweber; Ari Väänänen; Ida E. H. Madsen; Linda L. Magnusson Hanson; Mika Kivimäki; Hugo Westerlund; Jakob Bjorner; Marianna Virtanen; Andrew Steptoe; Reiner Rugulies; Jaana Pentti; Jane E. Ferrie; Eric Brunner; Olli Pietiläinen; Martin L. Nielsen; Töres Theorell; Ossi Rahkonen; Lars Alfredsson; Anders Knutsson; Katriina Heikkilä; Aki Koskinen; Sakari Suominen
Job Strain as a Risk Factor for Peripheral Artery Disease: A Multi-Cohort Study
Marianne Borritz
Tuula Oksanen
Tea Lallukka
Archana Singh‐Manoux
Jussi Vahtera
Hermann Burr
Solja T. Nyberg
Jan H. Pejtersen
Constanze Leineweber
Ari Väänänen
Ida E. H. Madsen
Linda L. Magnusson Hanson
Mika Kivimäki
Hugo Westerlund
Jakob Bjorner
Marianna Virtanen
Andrew Steptoe
Reiner Rugulies
Jaana Pentti
Jane E. Ferrie
Eric Brunner
Olli Pietiläinen
Martin L. Nielsen
Töres Theorell
Ossi Rahkonen
Lars Alfredsson
Anders Knutsson
Katriina Heikkilä
Aki Koskinen
Sakari Suominen
WILEY
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042713795
https://urn.fi/URN:NBN:fi-fe2021042713795
Tiivistelmä
Background: Job strain is implicated in many atherosclerotic diseases, but its role in peripheral artery disease (PAD) is unclear. We investigated the association of job strain with hospital records of PAD, using individual-level data from 11 prospective cohort studies from Finland, Sweden, Denmark, and the United Kingdom.
Methods and Results: Job strain (high demands and low control at work) was self-reported at baseline (1985-2008). PAD records were ascertained from national hospitalization data. We used Cox regression to examine the associations of job strain with PAD in each study, and combined the study-specific estimates in random effects meta-analyses. We used tau(2), I-2, and subgroup analyses to examine heterogeneity. Of the 139 132 participants with no previous hospitalization with PAD, 32 489 (23.4%) reported job strain at baseline. During 1 718 132 person-years at risk (mean follow-up 12.8 years), 667 individuals had a hospital record of PAD (3.88 per 10 000 person-years). Job strain was associated with a 1.41-fold (95% CI, 1.11-1.80) increased average risk of hospitalization with PAD. The study-specific estimates were moderately heterogeneous (tau(2)=0.0427, I-2: 26.9%). Despite variation in their magnitude, the estimates were consistent in both sexes, across the socioeconomic hierarchy and by baseline smoking status. Additional adjustment for baseline diabetes mellitus did not change the direction or magnitude of the observed associations.
Conclusions: Job strain was associated with small but consistent increase in the risk of hospitalization with PAD, with the relative risks on par with those for coronary heart disease and ischemic stroke.
Kokoelmat
- Rinnakkaistallenteet [19207]