Indoor-related microbe damage induces complement system activation in building users
Karhuvaara Outi; Nuutila Jari; Suominen Eetu; Atosuo Janne; Vilén Liisa; Putus Tuula
Indoor-related microbe damage induces complement system activation in building users
Karhuvaara Outi
Nuutila Jari
Suominen Eetu
Atosuo Janne
Vilén Liisa
Putus Tuula
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042827223
https://urn.fi/URN:NBN:fi-fe2021042827223
Tiivistelmä
In this comparative study, serum complement system antimicrobial activity was measured from 159 serum samples, taken from individuals from microbe-damaged (70 samples) and from reference buildings (89 samples). Antimicrobial activity was assessed using a probe-based bacterial Escherichia coli-lux bioluminescence system and comparison was made at a group level between the experimental and reference group. The complement activity was higher in users of microbe-damaged buildings compared with the reference group and the significant (P < 0.001) increase in activity was found in the classical reaction pathway. This study strengthens our notion that exposure to indoor-related microbe damage increases the risk for systemic subclinical inflammation and creates a health risk for building users.
Kokoelmat
- Rinnakkaistallenteet [19207]