Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient

Lotila Johanna; Hyvärinen Tarja; Skottman Heli; Airas Laura; Narkilahti Susanna; Hagman Sanna
Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient

Lotila Johanna
Hyvärinen Tarja
Skottman Heli
Airas Laura
Narkilahti Susanna
Hagman Sanna
Katso/Avaa
Lataukset: 

Elsevier B.V.
doi:10.1016/j.scr.2022.102865
URI
https://doi.org/10.1016/j.scr.2022.102865
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022091258631
Tiivistelmä

Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system where the main pathogenetic events include demyelination and axonal degeneration. Here, we generated a human induced pluripotent stem cell (hiPSC) line from peripheral blood mononuclear cells of an MS patient utilizing Sendai virus reprogramming. The produced hiPSC line expressed pluripotency markers, differentiated into three germ layers, showed a normal karyotype and was free of virus vectors, transgenes and mycoplasma. Established hiPSCs are a valuable source for studies of MS disease modeling and drug discovery.

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