Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Yuan XW; Liu C; Zhou WH; Cui WG; Qu XM; Wang YH; Zhang HB; Zou HX; Yan JQ; Li ZJ; Ma XD; Rosenholm JM
Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Yuan XW
Liu C
Zhou WH
Cui WG
Qu XM
Wang YH
Zhang HB
Zou HX
Yan JQ
Li ZJ
Ma XD
Rosenholm JM
Katso/Avaa
Lataukset: 

ROYAL SOC CHEMISTRY
doi:10.1039/d2bm00640e
URI
https://doi.org/10.1039/D2BM00640E
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022091258633
Tiivistelmä
Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.
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