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The effect of phytic acid on enzymatic degradation of dentin

Tezvergil-Mutluay Arzu; Thitthaweerat Suppason; Forgione Diletta; Seseogullari-Dirihan Roda; Nassar Mohannad

The effect of phytic acid on enzymatic degradation of dentin

Tezvergil-Mutluay Arzu
Thitthaweerat Suppason
Forgione Diletta
Seseogullari-Dirihan Roda
Nassar Mohannad
Katso/Avaa
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WILEY
doi:10.1111/eos.12771
URI
https://onlinelibrary.wiley.com/doi/10.1111/eos.12771
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021050328556
Tiivistelmä
We evaluated the effect of phytic acid on matrix metalloproteinase (MMP)- or cysteine cathepsin (CC)-mediated dentin degradation. Demineralized dentin beams were divided into five groups (n = 12) and treated with 1%, 2%, or 3% phytic acid or with 37% phosphoric acid. Untreated demineralized beams served as controls. After incubation for 1 or 3 wk, dry mass loss was determined and aliquots of incubation media were analysed for cross-linked telopeptide of type I collagen (ICTP) fragments for MMP-mediated and c-terminal telopeptide of type I collagen (CTX) for cathepsin-k-mediated degradation. The direct effect of phytic acid was evaluated using MMP activity assay. Data were analysed using repeated-measures anova. ICTP releases with 1% and 2% phytic acid treatment were statistically significantly lower than those following phosphoric acid treatment at 3 wk. The CTX release for phytic acid-treated beams at 3 wk was not significantly different from that of untreated control beams, but it was significantly lower than that of phosphoric acid-treated beams. Their MMP activities at 3 wk were not significantly different from those of the controls but they were significantly lower than those seen for phosphoric acid-treated beams. Compared to phosphoric acid, phytic acid treatment resulted in a reduced dentinal host-derived endogenous enzymatic activity and collagen degradation.
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  • Rinnakkaistallenteet [19207]

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