Scalable reaction network modeling with automatic validation of consistency in Event-B
Petre Ion; Hoang Thai Son; Sanwal Usman; Petre Luigia
Scalable reaction network modeling with automatic validation of consistency in Event-B
Petre Ion
Hoang Thai Son
Sanwal Usman
Petre Luigia
NATURE PORTFOLIO
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022081154382
https://urn.fi/URN:NBN:fi-fe2022081154382
Tiivistelmä
Constructing a large biological model is a difficult, error-prone process. Small errors in writing a part of the model cascade to the system level and their sources are difficult to trace back. In this paper we extend a recent approach based on Event-B, a state-based formal method with refinement as its central ingredient, allowing us to validate for model consistency step-by-step in an automated way. We demonstrate this approach on a model of the heat shock response in eukaryotes and its scalability on a model of the ErbB signaling pathway. All consistency properties of the model were proved automatically with computer support.
Kokoelmat
- Rinnakkaistallenteet [19207]