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Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women Results from the prospective controlled BREX exercise study

Kellokumpu-Lehtinen PL; Nikander R; Blomqvist C; Hakamies-Blomqvist L; Utriainen M; Kautiainen H; Huovinen R; Sintonen H; Saarto T; Penttinen H; Roine E; Vehmanen L

Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women Results from the prospective controlled BREX exercise study

Kellokumpu-Lehtinen PL
Nikander R
Blomqvist C
Hakamies-Blomqvist L
Utriainen M
Kautiainen H
Huovinen R
Sintonen H
Saarto T
Penttinen H
Roine E
Vehmanen L
Katso/Avaa
Publisher's version (613.9Kb)
Lataukset: 

doi:10.1016/j.breast.2021.06.012
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021102752641
Tiivistelmä

Abstract

Objective
To investigate long-term health-related quality of life (HRQoL) changes over time in younger compared to older disease-free breast cancer survivors who participated in a prospective randomized exercise trial.

Methods
Survivors (aged 35–68 years) were randomized to a 12-month exercise trial after adjuvant treatment and followed up for ten years. HRQoL was assessed with the generic 15D instrument during follow-up and the younger (baseline age ≤ 50) and older (age >50) survivors’ HRQoL was compared to that of the age-matched general female population (n = 892). The analysis included 342 survivors.

Results
The decline of HRQoL compared to the population was steeper and recovery slower in the younger survivors (p for interaction < 0.001). The impairment was also larger among the younger survivors (p = 0.027) whose mean HRQoL deteriorated for three years after treatment and started to slowly improve thereafter but still remained below the population level after ten years (difference −0.017, 95% CI: −0.031 to −0.004). The older survivors’ mean HRQoL gradually approached the population level during the first five years but also remained below it at ten years (difference −0.019, 95% CI: −0.031 to −0.007). The largest differences were on the dimensions of sleeping and sexual activity, on which both age groups remained below the population level throughout the follow-up.

Conclusions
HRQoL developed differently in younger and older survivors both regarding the most affected dimensions of HRQoL and the timing of the changes during follow-up. HRQoL of both age groups remained below the population level even ten years after treatment.

Kokoelmat
  • Rinnakkaistallenteet [19207]

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