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Preterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice

Ziv Oren; Rautava Samuli; Luoto Raakel; Salminen Seppo; Hiltunen Henni; Koren Omry; Hanani Hila; Turjeman Sondra; Isolauri Erika

dc.contributor.authorZiv Oren
dc.contributor.authorRautava Samuli
dc.contributor.authorLuoto Raakel
dc.contributor.authorSalminen Seppo
dc.contributor.authorHiltunen Henni
dc.contributor.authorKoren Omry
dc.contributor.authorHanani Hila
dc.contributor.authorTurjeman Sondra
dc.contributor.authorIsolauri Erika
dc.date.accessioned2022-10-28T13:33:41Z
dc.date.available2022-10-28T13:33:41Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/166032
dc.description.abstract<p>Preterm birth may result in adverse health outcomes. Very preterm infants typically exhibit postnatal growth restriction, metabolic disturbances, and exaggerated inflammatory responses. We investigated the differences in the meconium microbiota composition between very preterm (<32 weeks), moderately preterm (32-37 weeks), and term (>37 weeks) human neonates by 16S rRNA gene sequencing. Human meconium microbiota transplants to germ-free mice were conducted to investigate whether the meconium microbiota is causally related to the preterm infant phenotype in an experimental model. Our results indicate that very preterm birth is associated with a distinct meconium microbiota composition. Fecal microbiota transplant of very preterm infant meconium results in impaired growth, altered intestinal immune function, and metabolic parameters as compared to term infant meconium transplants in germ-free mice. This finding suggests that measures aiming to minimize the long-term adverse consequences of very preterm birth should be commenced during pregnancy or directly after birth.<br></p>
dc.language.isoen
dc.publisherELSEVIER
dc.titlePreterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S2666379121003153?via%3Dihub
dc.identifier.urnURN:NBN:fi-fe2022012710814
dc.relation.volume2
dc.contributor.organizationfi=lastentautioppi|en=Paediatrics and Adolescent Medicine|
dc.contributor.organizationfi=funktion. elint. kehittämiskeskus (yhteiset)|en=Functional Foods Forum|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organization-code2607020
dc.contributor.organization-code2607313
dc.converis.publication-id68304874
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/68304874
dc.identifier.eissn2666-3791
dc.identifier.jour-issn2666-3791
dc.okm.affiliatedauthorIsolauri, Erika
dc.okm.affiliatedauthorRautava, Samuli
dc.okm.affiliatedauthorLuoto, Raakel
dc.okm.affiliatedauthorHiltunen, Henni
dc.okm.affiliatedauthorSalminen, Seppo
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3123 Naisten- ja lastentauditfi_FI
dc.okm.discipline3123 Gynaecology and paediatricsen_GB
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.countryUnited Statesen_GB
dc.publisher.country-codeUS
dc.relation.articlenumberARTN 100447
dc.relation.doi10.1016/j.xcrm.2021.100447
dc.relation.ispartofjournalCell Reports Medicine
dc.relation.issue11
dc.year.issued2021


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