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Intracranial aneurysm is predicted by abdominal aortic calcification index: A retrospective case-control study

Kiviniemi Tuomas; Rinne Jaakko; Kivelev Juri; Saarenpää Ilkka; Lassila Elli; Gunn Jarmo; Hirvonen Jussi; Rantasalo Ville; Rahi Melissa; Laukka Dan

Intracranial aneurysm is predicted by abdominal aortic calcification index: A retrospective case-control study

Kiviniemi Tuomas
Rinne Jaakko
Kivelev Juri
Saarenpää Ilkka
Lassila Elli
Gunn Jarmo
Hirvonen Jussi
Rantasalo Ville
Rahi Melissa
Laukka Dan
Katso/Avaa
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Elsevier Ireland Ltd
doi:10.1016/j.atherosclerosis.2021.08.027
URI
https://www.sciencedirect.com/science/article/pii/S0021915021012880?via%3Dihub
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021093048696
Tiivistelmä

Background and aims

Patients with intracranial aneurysms (IA) have excess mortality for cardiovascular diseases, but little is known on whether atherosclerotic manifestations and IA coexist. We investigated abdominal aortic calcification index (ACI) association with unruptured and ruptured IAs.

Methods

This retrospective case-control study reviews all tertiary centers patients (n = 24,660) who had undergone head computed tomography angiography (CTA), magnetic resonance angiography (MRA) or digital subtraction angiography (DSA) for any reason between January 2003 and May 2018. Patients (n = 2020) with unruptured or ruptured IAs were identified, and patients with available abdominal CT were included. IA patients were matched by sex and age to controls (available abdomen CT, no IAs) in ratio of 1:3. ACI was measured from abdomen CT scans and patient records were reviewed.

Results

1720 patients (216 ruptured IA (rIA), 246 unruptured IA (UIA) and 1258 control) were included. Mean age was 62.9 ± 11.9 years and 58.2% were female. ACI (OR 1.02 per increment, 95%CI 1.01–1.03) and ACI>3 (OR 5.77, 95%CI 3.29–10.11) increased risk for rIA compared to matched controls. UIA patients' ACI was significantly higher but ACI did not increase odds for UIA compared to matched controls. History of coronary artery disease was less frequent in rIA patients. There was no calcification in aorta in 8.8% rIA and 13.6% UIA patients (matched controls 25.7% and 22.6% respectively, p < 0.01).

Conclusions

Aortic calcification is greater in rIA and UIA patients than matched controls. ACI increases risk for rIAs.

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  • Rinnakkaistallenteet [19207]

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