The genomics of heart failure: design and rationale of the HERMES consortium

Bloom Heather L.; Lindgren Cecilia M.; Dunn Michael E.; Kuchenbaecker Karoline; Shah Sonia; Xing Heming; Ghanbari Mohsen; Engström Gunnar; Lumbers R. Thomas; Esko Tõnu; Torp-Pedersen Christian; Wang Xiaosong; White Harvey D.; de Denus Simon; Dehghan Abbas; Andersson Charlotte; Haggerty Christopher M.; Morley Michael P.; Lovering Ruth C.; Perreault Louis-Philippe Lemieux; Chaffin Mark D.; Weeke Peter E.; O'Donoghue Michelle L.; Morrison Alanna C.; Jacob Jaison; Owens Anjali T.; Asselin Geraldine; Carey David J.; Vaura F; Portilla-Fernandez Eliana; Nowak Christoph; Nelson Christopher P.; Ghasemi Sahar; Tardif Jean-Claude; Yang Yifan; Finan Chris; Magnusson Patrik; Sveinbjörnsson Garðar; Smith J. Gustav; Mälarstig Anders; Czuba Tomasz; Mann Douglas; Brown Michael R.; Stefansson Kari; Doney Alexander S.; Kamanu Frederick; Dudley Samuel C.; Fatemifar Ghazaleh; Giulianini Franco; Asselbergs Folkert W.; Holm Hilma; Romaine Simon P.R.; Fouodjio René; Voors Adriaan A.; Chen Xing; Yu Bing; Tuckwell Danny; Gottdiener John S.; Mordi Ify R.; Gutmann Rebecca; Felix Stephan B.; Kleber Marcus E.; Uitterlinden Andre G.; Melander Olle; Yerges-Armstrong Laura M.; Lotta Luca A.; Lin Honghuang; Helgadottir Anna; Salomaa Veikko; Hyde Craig L.; Ärnlöv Johan; Cleland John G.F.; Teder-Laving Maris; Chutkow William; Brunner-La Rocca Hans-Peter; Zhao Faye; Khaw Kay-Tee; Hemingway Harry; Ellinor Patrick T.; Teumer Alexander; Fougerousse Francoise; Chen Xu; Nagle Michael W.; Wiggins Kerri L.; Melloni Giorgio; Denaxas Spiros; Holmes Michael V.; Thorgeirsson Guðmundur; McMurray John J.V.; Taylor Kent D.; Hedman Åsa K.; Wareham Nicholas J.; Ruff Christian T.; Chasman Daniel I.; Stott David J.; Hillege Hans; Rotter Jerome I.; Psaty Bruce M.; März Winfried; Wilk Jemma B.; Yang Jian; Morris Andrew P.; Dubé Marie-Pierre; Cook James P.; Thorsteinsdottir Unnur; Weiss Raul; Shah Svati; Vasan Ramachandran S.; Lang Chim C.; Koekemoer Andrea; Kardys Isabella; van der Harst Pim; Chazara Olympe; Gui Hongsheng; Niiranen Teemu; Kraus Bill; Ford Ian; Sabatine Marc S.; Dörr Marcus; Völker Uwe; Delgado Graciela E.; Almgren Peter; Wells Quinn S.; Zannad Faiez; Salo Perttu; Lind Lars; Brandimarto Jeffrey; Giedraitis Vilmantas; Jukema J. Wouter; Gross Stefan; Chung Jonathan H.; Langenberg Claudia; Palmer Colin N.A.; Shalaby Alaa A.; Luan Jian’an; Perola Markus; Aragam Krishna G.; Stender Steen; Verweij Niek; Roselli Carolina; Cappola Thomas P.; Morris Andrew D.; Guðbjartsson Daníel F.; Trompet Stella; Hingorani Aroon D.; Mahajan Anubha; Newton-Cheh Christopher; Biggs Mary L.L; Swerdlow Daniel I.; Backman Joshua D.; Smith Nicholas L.; Marston Nicholas A.; Visscher Peter M.; Lubitz Steven A.; Rice Kenneth M.; Margulies Kenneth B.; Kavousi Maryam; Køber Lars; Niessner Alexander; Ridker Paul M.; Boersma Eric; Tyl Benoit; Samani Nilesh J.; Sattar Naveed; Lanfear David E.; Veluchamy Abirami; London Barry; Smelser Diane T.; van Setten Jessica; Tammesoo Mari-Liis; Sallah Neneh; Svensson Per; Paré Guillaume; Henry Albert
The genomics of heart failure: design and rationale of the HERMES consortium

Bloom Heather L.
Lindgren Cecilia M.
Dunn Michael E.
Kuchenbaecker Karoline
Shah Sonia
Xing Heming
Ghanbari Mohsen
Engström Gunnar
Lumbers R. Thomas
Esko Tõnu
Torp-Pedersen Christian
Wang Xiaosong
White Harvey D.
de Denus Simon
Dehghan Abbas
Andersson Charlotte
Haggerty Christopher M.
Morley Michael P.
Lovering Ruth C.
Perreault Louis-Philippe Lemieux
Chaffin Mark D.
Weeke Peter E.
O'Donoghue Michelle L.
Morrison Alanna C.
Jacob Jaison
Owens Anjali T.
Asselin Geraldine
Carey David J.
Vaura F
Portilla-Fernandez Eliana
Nowak Christoph
Nelson Christopher P.
Ghasemi Sahar
Tardif Jean-Claude
Yang Yifan
Finan Chris
Magnusson Patrik
Sveinbjörnsson Garðar
Smith J. Gustav
Mälarstig Anders
Czuba Tomasz
Mann Douglas
Brown Michael R.
Stefansson Kari
Doney Alexander S.
Kamanu Frederick
Dudley Samuel C.
Fatemifar Ghazaleh
Giulianini Franco
Asselbergs Folkert W.
Holm Hilma
Romaine Simon P.R.
Fouodjio René
Voors Adriaan A.
Chen Xing
Yu Bing
Tuckwell Danny
Gottdiener John S.
Mordi Ify R.
Gutmann Rebecca
Felix Stephan B.
Kleber Marcus E.
Uitterlinden Andre G.
Melander Olle
Yerges-Armstrong Laura M.
Lotta Luca A.
Lin Honghuang
Helgadottir Anna
Salomaa Veikko
Hyde Craig L.
Ärnlöv Johan
Cleland John G.F.
Teder-Laving Maris
Chutkow William
Brunner-La Rocca Hans-Peter
Zhao Faye
Khaw Kay-Tee
Hemingway Harry
Ellinor Patrick T.
Teumer Alexander
Fougerousse Francoise
Chen Xu
Nagle Michael W.
Wiggins Kerri L.
Melloni Giorgio
Denaxas Spiros
Holmes Michael V.
Thorgeirsson Guðmundur
McMurray John J.V.
Taylor Kent D.
Hedman Åsa K.
Wareham Nicholas J.
Ruff Christian T.
Chasman Daniel I.
Stott David J.
Hillege Hans
Rotter Jerome I.
Psaty Bruce M.
März Winfried
Wilk Jemma B.
Yang Jian
Morris Andrew P.
Dubé Marie-Pierre
Cook James P.
Thorsteinsdottir Unnur
Weiss Raul
Shah Svati
Vasan Ramachandran S.
Lang Chim C.
Koekemoer Andrea
Kardys Isabella
van der Harst Pim
Chazara Olympe
Gui Hongsheng
Niiranen Teemu
Kraus Bill
Ford Ian
Sabatine Marc S.
Dörr Marcus
Völker Uwe
Delgado Graciela E.
Almgren Peter
Wells Quinn S.
Zannad Faiez
Salo Perttu
Lind Lars
Brandimarto Jeffrey
Giedraitis Vilmantas
Jukema J. Wouter
Gross Stefan
Chung Jonathan H.
Langenberg Claudia
Palmer Colin N.A.
Shalaby Alaa A.
Luan Jian’an
Perola Markus
Aragam Krishna G.
Stender Steen
Verweij Niek
Roselli Carolina
Cappola Thomas P.
Morris Andrew D.
Guðbjartsson Daníel F.
Trompet Stella
Hingorani Aroon D.
Mahajan Anubha
Newton-Cheh Christopher
Biggs Mary L.L
Swerdlow Daniel I.
Backman Joshua D.
Smith Nicholas L.
Marston Nicholas A.
Visscher Peter M.
Lubitz Steven A.
Rice Kenneth M.
Margulies Kenneth B.
Kavousi Maryam
Køber Lars
Niessner Alexander
Ridker Paul M.
Boersma Eric
Tyl Benoit
Samani Nilesh J.
Sattar Naveed
Lanfear David E.
Veluchamy Abirami
London Barry
Smelser Diane T.
van Setten Jessica
Tammesoo Mari-Liis
Sallah Neneh
Svensson Per
Paré Guillaume
Henry Albert
Katso/Avaa
Lataukset: 

WILEY PERIODICALS, INC
doi:10.1002/ehf2.13517
URI
https://onlinelibrary.wiley.com/doi/10.1002/ehf2.13517
Näytä kaikki kuvailutiedot
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021102752658
Tiivistelmä

Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targets) consortium aims to identify the genomic and molecular basis of heart failure.

Methods and results The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of >1.10 for common variants (allele frequency > 0.05) and >1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 x 10(-8) under an additive genetic model.

Conclusions HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.

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