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Effects of reduced sedentary time on cardiometabolic health in adults with metabolic syndrome: A three-month randomized controlled trial

Heinonen Ilkka; Löyttyniemi Eliisa; Houttu Noora; Kalliokoski Kari; Sjöros Tanja; Sievänen H.; Knuuti Juhani; Garthwaite Taru; Vasankari Tommi; Vähä-Ypyä Henri; Laine Saara; Laitinen Kirsi

dc.contributor.authorHeinonen Ilkka
dc.contributor.authorLöyttyniemi Eliisa
dc.contributor.authorHouttu Noora
dc.contributor.authorKalliokoski Kari
dc.contributor.authorSjöros Tanja
dc.contributor.authorSievänen H.
dc.contributor.authorKnuuti Juhani
dc.contributor.authorGarthwaite Taru
dc.contributor.authorVasankari Tommi
dc.contributor.authorVähä-Ypyä Henri
dc.contributor.authorLaine Saara
dc.contributor.authorLaitinen Kirsi
dc.date.accessioned2022-10-28T13:40:28Z
dc.date.available2022-10-28T13:40:28Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/166626
dc.description.abstract<h3>Objectives</h3><p>To investigate if reducing sedentary behavior improves cardiometabolic biomarkers in adults with <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/metabolic-syndrome-x" title="Learn more about metabolic syndrome from ScienceDirect's AI-generated Topic Pages">metabolic syndrome</a>.</p><h3>Design</h3><p>Randomized controlled trial.</p><h3>Methods</h3><p>Sixty-four sedentary middle-aged adults with metabolic syndrome were randomized into intervention (INT; n = 33) and control (CON; n = 31) groups. INT was guided to limit sedentary behavior by 1 h/day through increased standing and light-intensity physical activity. CON was instructed to maintain usual habits. Sedentary behavior, breaks in sedentary behavior, standing, and physical activity were measured with hip-worn <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/accelerometer" title="Learn more about accelerometers from ScienceDirect's AI-generated Topic Pages">accelerometers</a> for three months. Fasting blood sampling and measurements of <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/anthropometry" title="Learn more about anthropometrics from ScienceDirect's AI-generated Topic Pages">anthropometrics</a>, body composition, and blood pressure were performed at baseline and at three months. Linear mixed models were used for statistical analyses.</p><h3>Results</h3><p>INT reduced sedentary behavior by 50 (95% CI: 24, 73) min/day by increasing light-intensity and moderate-to-vigorous physical activity (19 [8, 30] and 24 [14, 34] min/day, respectively). Standing increased also, but non-significantly (6 [−11, 23] min/day). CON maintained baseline activity levels. Significant intervention effects favoring INT occurred in fasting insulin (INT: 83.4 [68.7, 101.2] vs. CON: 102.0 [83.3, 125.0] pmol/l at three months), insulin resistance (HOMA-IR; 3.2 [2.6, 3.9] vs. 4.0 [3.2, 4.9]), HbA<sub>1c</sub> (37 [36, 38] vs. 38 [37, 39] mmol/mol), and <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/liver-enzyme" title="Learn more about liver enzyme from ScienceDirect's AI-generated Topic Pages">liver enzyme</a> <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/alanine-aminotransferase" title="Learn more about alanine aminotransferase from ScienceDirect's AI-generated Topic Pages">alanine aminotransferase</a> (28 [24, 33] vs. 33 [28, 38] U/l).</p><h3>Conclusions</h3><p>Reducing sedentary behavior by 50 min/day and increasing light-intensity and moderate-to-vigorous activity showed benefits in several cardiometabolic biomarkers in adults with metabolic syndrome. Replacing some of the daily sedentary behavior with light-intensity and moderate-to-vigorous physical activity may help in cardiometabolic disease prevention in risk populations.</p><p><br></p>
dc.language.isoen
dc.publisherElsevier Ltd
dc.titleEffects of reduced sedentary time on cardiometabolic health in adults with metabolic syndrome: A three-month randomized controlled trial
dc.identifier.urlhttps://doi.org/10.1016/j.jsams.2022.04.002
dc.identifier.urnURN:NBN:fi-fe2022081154605
dc.relation.volume25
dc.contributor.organizationfi=biolääketieteen laitos, yhteiset|en=Institute of Biomedicine|
dc.contributor.organizationfi=InFLAMES lippulaiva, tutkimus|en=InFLAMES Flagship, research|
dc.contributor.organizationfi=funktion. elint. kehittämiskeskus (yhteiset)|en=Functional Foods Forum|
dc.contributor.organizationfi=biostatistiikka|en=Biostatistics|
dc.contributor.organizationfi=PET perustoiminta|en=PET Basic Operations|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organizationfi=kliininen fysiologia ja isotooppilääketiede|en=Clinical Physiology and Nuclear Medicine|
dc.contributor.organization-code2607051
dc.contributor.organization-code2607100
dc.contributor.organization-code2607302
dc.contributor.organization-code2609810
dc.contributor.organization-code2607020
dc.contributor.organization-code2607322
dc.converis.publication-id175657639
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/175657639
dc.format.pagerange585
dc.format.pagerange579
dc.identifier.jour-issn1440-2440
dc.okm.affiliatedauthorHeinonen, Ilkka
dc.okm.affiliatedauthorLaine, Saara
dc.okm.affiliatedauthorSjöros, Tanja
dc.okm.affiliatedauthorKalliokoski, Kari
dc.okm.affiliatedauthorLaitinen, Kirsi
dc.okm.affiliatedauthorHouttu, Noora
dc.okm.affiliatedauthorGarthwaite, Taru
dc.okm.affiliatedauthorKnuuti, Juhani
dc.okm.affiliatedauthorLöyttyniemi, Eliisa
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.discipline315 Sport and fitness sciencesen_GB
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.discipline315 Liikuntatiedefi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countryNetherlandsen_GB
dc.publisher.countryAlankomaatfi_FI
dc.publisher.country-codeNL
dc.relation.doi10.1016/j.jsams.2022.04.002
dc.relation.ispartofjournalJournal of Science and Medicine in Sport
dc.relation.issue7
dc.year.issued2022


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