dc.contributor.author | Heinonen Ilkka | |
dc.contributor.author | Löyttyniemi Eliisa | |
dc.contributor.author | Houttu Noora | |
dc.contributor.author | Kalliokoski Kari | |
dc.contributor.author | Sjöros Tanja | |
dc.contributor.author | Sievänen H. | |
dc.contributor.author | Knuuti Juhani | |
dc.contributor.author | Garthwaite Taru | |
dc.contributor.author | Vasankari Tommi | |
dc.contributor.author | Vähä-Ypyä Henri | |
dc.contributor.author | Laine Saara | |
dc.contributor.author | Laitinen Kirsi | |
dc.date.accessioned | 2022-10-28T13:40:28Z | |
dc.date.available | 2022-10-28T13:40:28Z | |
dc.identifier.uri | https://www.utupub.fi/handle/10024/166626 | |
dc.description.abstract | <h3>Objectives</h3><p>To investigate if reducing sedentary behavior improves cardiometabolic biomarkers in adults with <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/metabolic-syndrome-x" title="Learn more about metabolic syndrome from ScienceDirect's AI-generated Topic Pages">metabolic syndrome</a>.</p><h3>Design</h3><p>Randomized controlled trial.</p><h3>Methods</h3><p>Sixty-four sedentary middle-aged adults with metabolic syndrome were randomized into intervention (INT; n = 33) and control (CON; n = 31) groups. INT was guided to limit sedentary behavior by 1 h/day through increased standing and light-intensity physical activity. CON was instructed to maintain usual habits. Sedentary behavior, breaks in sedentary behavior, standing, and physical activity were measured with hip-worn <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/accelerometer" title="Learn more about accelerometers from ScienceDirect's AI-generated Topic Pages">accelerometers</a> for three months. Fasting blood sampling and measurements of <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/anthropometry" title="Learn more about anthropometrics from ScienceDirect's AI-generated Topic Pages">anthropometrics</a>, body composition, and blood pressure were performed at baseline and at three months. Linear mixed models were used for statistical analyses.</p><h3>Results</h3><p>INT reduced sedentary behavior by 50 (95% CI: 24, 73) min/day by increasing light-intensity and moderate-to-vigorous physical activity (19 [8, 30] and 24 [14, 34] min/day, respectively). Standing increased also, but non-significantly (6 [−11, 23] min/day). CON maintained baseline activity levels. Significant intervention effects favoring INT occurred in fasting insulin (INT: 83.4 [68.7, 101.2] vs. CON: 102.0 [83.3, 125.0] pmol/l at three months), insulin resistance (HOMA-IR; 3.2 [2.6, 3.9] vs. 4.0 [3.2, 4.9]), HbA<sub>1c</sub> (37 [36, 38] vs. 38 [37, 39] mmol/mol), and <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/liver-enzyme" title="Learn more about liver enzyme from ScienceDirect's AI-generated Topic Pages">liver enzyme</a> <a href="https://www.sciencedirect.com/topics/nursing-and-health-professions/alanine-aminotransferase" title="Learn more about alanine aminotransferase from ScienceDirect's AI-generated Topic Pages">alanine aminotransferase</a> (28 [24, 33] vs. 33 [28, 38] U/l).</p><h3>Conclusions</h3><p>Reducing sedentary behavior by 50 min/day and increasing light-intensity and moderate-to-vigorous activity showed benefits in several cardiometabolic biomarkers in adults with metabolic syndrome. Replacing some of the daily sedentary behavior with light-intensity and moderate-to-vigorous physical activity may help in cardiometabolic disease prevention in risk populations.</p><p><br></p> | |
dc.language.iso | en | |
dc.publisher | Elsevier Ltd | |
dc.title | Effects of reduced sedentary time on cardiometabolic health in adults with metabolic syndrome: A three-month randomized controlled trial | |
dc.identifier.url | https://doi.org/10.1016/j.jsams.2022.04.002 | |
dc.identifier.urn | URN:NBN:fi-fe2022081154605 | |
dc.relation.volume | 25 | |
dc.contributor.organization | fi=biolääketieteen laitos, yhteiset|en=Institute of Biomedicine| | |
dc.contributor.organization | fi=InFLAMES lippulaiva, tutkimus|en=InFLAMES Flagship, research| | |
dc.contributor.organization | fi=funktion. elint. kehittämiskeskus (yhteiset)|en=Functional Foods Forum| | |
dc.contributor.organization | fi=biostatistiikka|en=Biostatistics| | |
dc.contributor.organization | fi=PET perustoiminta|en=PET Basic Operations| | |
dc.contributor.organization | fi=tyks, vsshp|en=tyks, vsshp| | |
dc.contributor.organization | fi=kliininen fysiologia ja isotooppilääketiede|en=Clinical Physiology and Nuclear Medicine| | |
dc.contributor.organization-code | 2607051 | |
dc.contributor.organization-code | 2607100 | |
dc.contributor.organization-code | 2607302 | |
dc.contributor.organization-code | 2609810 | |
dc.contributor.organization-code | 2607020 | |
dc.contributor.organization-code | 2607322 | |
dc.converis.publication-id | 175657639 | |
dc.converis.url | https://research.utu.fi/converis/portal/Publication/175657639 | |
dc.format.pagerange | 585 | |
dc.format.pagerange | 579 | |
dc.identifier.jour-issn | 1440-2440 | |
dc.okm.affiliatedauthor | Heinonen, Ilkka | |
dc.okm.affiliatedauthor | Laine, Saara | |
dc.okm.affiliatedauthor | Sjöros, Tanja | |
dc.okm.affiliatedauthor | Kalliokoski, Kari | |
dc.okm.affiliatedauthor | Laitinen, Kirsi | |
dc.okm.affiliatedauthor | Houttu, Noora | |
dc.okm.affiliatedauthor | Garthwaite, Taru | |
dc.okm.affiliatedauthor | Knuuti, Juhani | |
dc.okm.affiliatedauthor | Löyttyniemi, Eliisa | |
dc.okm.affiliatedauthor | Dataimport, tyks, vsshp | |
dc.okm.discipline | 3121 Internal medicine | en_GB |
dc.okm.discipline | 315 Sport and fitness sciences | en_GB |
dc.okm.discipline | 3111 Biomedicine | en_GB |
dc.okm.discipline | 3111 Biolääketieteet | fi_FI |
dc.okm.discipline | 3121 Sisätaudit | fi_FI |
dc.okm.discipline | 315 Liikuntatiede | fi_FI |
dc.okm.internationalcopublication | international co-publication | |
dc.okm.internationality | International publication | |
dc.okm.type | Journal article | |
dc.publisher.country | Netherlands | en_GB |
dc.publisher.country | Alankomaat | fi_FI |
dc.publisher.country-code | NL | |
dc.relation.doi | 10.1016/j.jsams.2022.04.002 | |
dc.relation.ispartofjournal | Journal of Science and Medicine in Sport | |
dc.relation.issue | 7 | |
dc.year.issued | 2022 | |