Early probiotic supplementation and the risk of celiac disease in children at genetic risk
Ulla Uusitalo; Christiane Winkler; Daniel Agardh; on behalf of the TEDDY Study Group; Jill M. Norris; Kalle Kurppa; Anette-G. Ziegler; Marian J. Rewers; Carin Andren Aronsson; Edwin Liu; William A. Hagopian; Jeffrey P. Krischer; Jorma Toppari; Beena Akolkar; Xiang Liu; Jennifer Skidmore; Jimin Yang; Suvi M. Virtanen; Jin-Xiong She
Early probiotic supplementation and the risk of celiac disease in children at genetic risk
Ulla Uusitalo
Christiane Winkler
Daniel Agardh; on behalf of the TEDDY Study Group
Jill M. Norris
Kalle Kurppa
Anette-G. Ziegler
Marian J. Rewers
Carin Andren Aronsson
Edwin Liu
William A. Hagopian
Jeffrey P. Krischer
Jorma Toppari
Beena Akolkar
Xiang Liu
Jennifer Skidmore
Jimin Yang
Suvi M. Virtanen
Jin-Xiong She
MDPI AG
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042822897
Probiotics are linked to positive regulatory effects on the immune
system. The aim of the study was to examine the association between the
exposure of probiotics via dietary supplements or via infant formula by
the age of 1 year and the development of celiac disease autoimmunity
(CDA) and celiac disease among a cohort of 6520 genetically susceptible
children. Use of probiotics during the first year of life was reported
by 1460 children. Time-to-event analysis was used to examine the
associations. Overall exposure of probiotics during the first year of
life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p
= 0.43) when adjusting for known risk factors. Intake of probiotic
dietary supplements, however, was associated with a slightly increased
risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p
= 0.043) compared to children who did not get probiotics. It was
concluded that the overall exposure of probiotics during the first year
of life was not associated with CDA or celiac disease in children at
genetic risk.
https://urn.fi/URN:NBN:fi-fe2021042822897
Tiivistelmä
Probiotics are linked to positive regulatory effects on the immune
system. The aim of the study was to examine the association between the
exposure of probiotics via dietary supplements or via infant formula by
the age of 1 year and the development of celiac disease autoimmunity
(CDA) and celiac disease among a cohort of 6520 genetically susceptible
children. Use of probiotics during the first year of life was reported
by 1460 children. Time-to-event analysis was used to examine the
associations. Overall exposure of probiotics during the first year of
life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p
= 0.43) when adjusting for known risk factors. Intake of probiotic
dietary supplements, however, was associated with a slightly increased
risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p
= 0.043) compared to children who did not get probiotics. It was
concluded that the overall exposure of probiotics during the first year
of life was not associated with CDA or celiac disease in children at
genetic risk.
Kokoelmat
- Rinnakkaistallenteet [19207]