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Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors: Data from the EuroSpA collaboration

Wallman Johan K.; Giuseppe Daniela Di; Nissen Michael J.; van sder Horst-Bruinsma Irene; Santos Helena.; Gudbjornsson Bjorn; Rasmussen Simon H.; Rotar Ziga; Pavelka Karel; Corrado Addolorata; Závada Jakub; Gunduz Ozgul S.; Østergaard Mikkel; Geirsson Arni Jon; Jones Gareth T.; Tomšič Matija; Laas Karin; Santos Maria J.; Glintborg Bente; Pirilä Laura; Michelsen Brigitte; Akkoc Nurullah; Codreanu Catalin; Relas Heikki; Ciurea Adrian; Georgiadis Stylianos; Linde Louise; Lindström Ulf; Kristianslund Eirik K.; Iannone Florenzo; Hetland Merete Lund; Ørnbjerg Lykke M.; Loft Anne Gitte; Askling Johan

Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors: Data from the EuroSpA collaboration

Wallman Johan K.
Giuseppe Daniela Di
Nissen Michael J.
van sder Horst-Bruinsma Irene
Santos Helena.
Gudbjornsson Bjorn
Rasmussen Simon H.
Rotar Ziga
Pavelka Karel
Corrado Addolorata
Závada Jakub
Gunduz Ozgul S.
Østergaard Mikkel
Geirsson Arni Jon
Jones Gareth T.
Tomšič Matija
Laas Karin
Santos Maria J.
Glintborg Bente
Pirilä Laura
Michelsen Brigitte
Akkoc Nurullah
Codreanu Catalin
Relas Heikki
Ciurea Adrian
Georgiadis Stylianos
Linde Louise
Lindström Ulf
Kristianslund Eirik K.
Iannone Florenzo
Hetland Merete Lund
Ørnbjerg Lykke M.
Loft Anne Gitte
Askling Johan
Katso/Avaa
1-s2.0-S0049017222001329-main.pdf (1.328Mb)
Lataukset: 

W.B. Saunders
doi:10.1016/j.semarthrit.2022.152081
URI
https://www.sciencedirect.com/science/article/pii/S0049017222001329?via%3Dihub
Näytä kaikki kuvailutiedot
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022102463114
Tiivistelmä

Objectives
In patients with axial spondyloarthritis (axSpA) initiating their first tumor necrosis factor alpha-inhibitor (TNFi), we aimed to identify common baseline predictors of Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP) inactive disease (primary objective) and clinically important improvement (CII) at 6 months, and drug retention at 12-months across 15 European registries.

Methods
Baseline demographic and clinical characteristics were collected. Outcomes were investigated per registry and in pooled data using logistic regression analyses on multiply imputed data.

Results
The consistency of baseline predictors in individual registries justified pooling the data. In the pooled dataset (n = 21,196), the 6-month rates for ASDAS inactive disease and ASDAS CII were 26% and 51%, and the 12-month drug retention rate 65% in patients with available data (n = 9,845, n = 6,948 and n = 21,196, respectively). Nine common baseline predictors of ASDAS inactive disease, ASDAS CII and 12-month drug retention were identified, and the odds ratios (95%-confidence interval) for ASDAS inactive disease were: age, per year: 0.97 (0.97–0.98), men vs. women: 1.88 (1.60–2.22), current vs. non-smoking: 0.76 (0.63–0.91), HLA-B27 positive vs. negative: 1.51 (1.20–1.91), TNF start year 2015–2018 vs. 2009–2014: 1.24 (1.06–1.45), CRP>10 vs. ≤10 mg/l: 1.49 (1.25–1.77), one unit increase in health assessment questionnaire (HAQ): 0.77 (0.58–1.03), one-millimeter (mm) increase in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) fatigue and spinal pain: 0.99 (0.99–1.00) and 0.99 (0.99–1.99), respectively

Conclusion
Common baseline predictors of treatment response and adherence to TNFi could be identified across data from 15 European registries, indicating that they may be universal across different axSpA populations.

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