Näytä suppeat kuvailutiedot

Determinants of left ventricular diastolic function-The Cardiovascular Risk in Young Finns Study

Kähönen M; Rovio SP; Hutri-Kähonen N; Viikari JSA; Juonala M; Raitakari OT; Heiskanen JS; Tossavainen P; Laitinen T; Lehtimäki T; Jokinen E; Kytö V; Ruohonen S

dc.contributor.authorKähönen M
dc.contributor.authorRovio SP
dc.contributor.authorHutri-Kähonen N
dc.contributor.authorViikari JSA
dc.contributor.authorJuonala M
dc.contributor.authorRaitakari OT
dc.contributor.authorHeiskanen JS
dc.contributor.authorTossavainen P
dc.contributor.authorLaitinen T
dc.contributor.authorLehtimäki T
dc.contributor.authorJokinen E
dc.contributor.authorKytö V
dc.contributor.authorRuohonen S
dc.date.accessioned2022-10-28T13:42:40Z
dc.date.available2022-10-28T13:42:40Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/166891
dc.description.abstractDecreased left ventricular (LV) diastolic function is associated with increased all-cause mortality and risk for a heart failure. The determinants of LV diastolic function have been mainly studied in elderly populations; however, the origin of LV heart failure may relate to the lifestyle factors acquired during the life course. Therefore, we examined biochemical, physiological, and lifestyle determinants of LV diastolic function in 34-49-year-old participants of the Cardiovascular Risk in Young Finns Study (Young Finns Study). In 2011, clinical examination and echocardiography were performed for 1928 participants (880 men and 1048 women; aged 34-49 years). LV diastolic function was primarily defined using E/e-ratio (population mean 4.8, range 2.1-9.0). In a multivariate model, systolic blood pressure (P < 0.005), female sex (P < 0.005), age (P < 0.005), waist circumference (P = 0.024), smoking (P = 0.028), serum alanine aminotransferase (P = 0.032) were directly associated with E/e-ratio, while an inverse association was found for height (P < 0.005). Additionally, a higher E/e-ratio was found in participants with concentric hypertrophy compared to normal cardiac geometry (P < 0.005). Other indicators of the LV diastolic function including E/A-ratio and left atrial volume index showed similarly strong associations with systolic blood pressure and age. In conclusion, we identified systolic blood pressure, waist circumference and smoking as modifiable determinants of the LV diastolic function in the 34-49-year-old participants of the Young Finns Study.
dc.language.isoen
dc.publisherWILEY
dc.titleDeterminants of left ventricular diastolic function-The Cardiovascular Risk in Young Finns Study
dc.identifier.urnURN:NBN:fi-fe2021042823094
dc.relation.volume36
dc.contributor.organizationfi=sydäntutkimuskeskus|en=Research Centre of Applied and Preventive Cardiovascular Medicine (CAPC)|
dc.contributor.organizationfi=kliinisen laitoksen yhteiset|en=Department of Clinical Medicine|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organizationfi=sisätautioppi|en=Internal Medicine|
dc.contributor.organization-code2607318
dc.contributor.organization-code2607004
dc.contributor.organization-code2607300
dc.converis.publication-id41079938
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/41079938
dc.format.pagerange861
dc.format.pagerange854
dc.identifier.eissn1540-8175
dc.identifier.jour-issn0742-2822
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorJuonala, Markus
dc.okm.affiliatedauthorViikari, Jorma
dc.okm.affiliatedauthorRovio, Suvi
dc.okm.affiliatedauthorHeiskanen, Jarkko
dc.okm.affiliatedauthorKytö, Ville
dc.okm.affiliatedauthorRaitakari, Olli
dc.okm.discipline3126 Surgery, anesthesiology, intensive care, radiologyen_GB
dc.okm.discipline3126 Kirurgia, anestesiologia, tehohoito, radiologiafi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.countryUnited Statesen_GB
dc.publisher.country-codeUS
dc.relation.doi10.1111/echo.14321
dc.relation.ispartofjournalEchocardiography
dc.relation.issue5
dc.year.issued2019


Aineistoon kuuluvat tiedostot

Thumbnail

Aineisto kuuluu seuraaviin kokoelmiin

Näytä suppeat kuvailutiedot