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Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multinational cohort

Le Roux Pascal; Morais-Almeida Mário; El-Owaidy Rasha; Chen Zhimin; Xu Dan; PeARL collaborators; on behalf of the PeARL Think Tank; Garcia Antonio Nieto; Villalobos Yunuen R Huerta; Castro-Rodriguez Jose A; Mathioudakis Alexander G; Nagaraju Karthik; Levina Julia; Xepapadaki Paraskevi; Deschildre Antoine; Nagaraju Major K; Rodriguez Elsy Maureen Navarrete; Wasilczuk Katarzyna; Zagal Eréndira Rodríguez; Feleszko Wojciech; Ramos Ángel Mazón; Fiocchi Alessandro; Custovic Adnan; Phipatanakul Wanda; Abou-Taam Rola; El-Sayed Zeinab Awad; Tulkki Marleena; Schweitzer Cyril E; Jartti Tuomas; Murray Clare; Dubus Jean-Christophe; Ratchataswan Thanaporn; Cros Pierrick; Beltran Cesar Fireth Pozo; Papadopoulos Nikolaos G; Yeverino Daniela Rivero; Hossny Elham M; Namazova-Baranova Leyla; Garcia Aida Inés López; Fierro Vincenzo; Agache Ioana; Goh Anne; Wong Gary; Garcia-Marcos Luis

Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multinational cohort

Le Roux Pascal
Morais-Almeida Mário
El-Owaidy Rasha
Chen Zhimin
Xu Dan; PeARL collaborators; on behalf of the PeARL Think Tank
Garcia Antonio Nieto
Villalobos Yunuen R Huerta
Castro-Rodriguez Jose A
Mathioudakis Alexander G
Nagaraju Karthik
Levina Julia
Xepapadaki Paraskevi
Deschildre Antoine
Nagaraju Major K
Rodriguez Elsy Maureen Navarrete
Wasilczuk Katarzyna
Zagal Eréndira Rodríguez
Feleszko Wojciech
Ramos Ángel Mazón
Fiocchi Alessandro
Custovic Adnan
Phipatanakul Wanda
Abou-Taam Rola
El-Sayed Zeinab Awad
Tulkki Marleena
Schweitzer Cyril E
Jartti Tuomas
Murray Clare
Dubus Jean-Christophe
Ratchataswan Thanaporn
Cros Pierrick
Beltran Cesar Fireth Pozo
Papadopoulos Nikolaos G
Yeverino Daniela Rivero
Hossny Elham M
Namazova-Baranova Leyla
Garcia Aida Inés López
Fierro Vincenzo
Agache Ioana
Goh Anne
Wong Gary
Garcia-Marcos Luis
Katso/Avaa
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WILEY
doi:10.1111/all.14787
URI
https://onlinelibrary.wiley.com/doi/10.1111/all.14787
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021050328576
Tiivistelmä

Background

The interplay between COVID-19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID-19 pandemic on childhood asthma outcomes.

Methods

The PeARL multinational cohort included 1,054 children with asthma and 505 non-asthmatic children aged between 4 and 18 years from 25 pediatric departments, from 15 countries globally. We compared the frequency of acute respiratory and febrile presentations during the first wave of the COVID-19 pandemic between groups and with data available from the previous year. In children with asthma, we also compared current and historical disease control.

Results

During the pandemic, children with asthma experienced fewer upper respiratory tract infections, episodes of pyrexia, emergency visits, hospital admissions, asthma attacks, and hospitalizations due to asthma, in comparison with the preceding year. Sixty-six percent of asthmatic children had improved asthma control while in 33% the improvement exceeded the minimal clinically important difference. Pre-bronchodilatation FEV1 and peak expiratory flow rate were improved during the pandemic. When compared to non-asthmatic controls, children with asthma were not at increased risk of LRTIs, episodes of pyrexia, emergency visits, or hospitalizations during the pandemic. However, an increased risk of URTIs emerged.

Conclusion

Childhood asthma outcomes, including control, were improved during the first wave of the COVID-19 pandemic, probably because of reduced exposure to asthma triggers and increased treatment adherence. The decreased frequency of acute episodes does not support the notion that childhood asthma may be a risk factor for COVID-19. Furthermore, the potential for improving childhood asthma outcomes through environmental control becomes apparent.

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