Childhood BMI and Fasting Glucose and Insulin Predict Adult Type 2 Diabetes: The International Childhood Cardiovascular Cohort (i3C) Consortium
Venn Alison; Daniels Stephen R; Woo Jessica G; Urbina Elaine M; Juonala Markus; Murdy Kari A; Prineas Ronald J; Steinberger Julia; Jacobs David R; Dwyer Terry; Burns Trudy L; Hutri-Kähonen Nina; Sinaiko Alan R; Bazzano Lydia A; Raitakari Olli T; Hu Tian
Childhood BMI and Fasting Glucose and Insulin Predict Adult Type 2 Diabetes: The International Childhood Cardiovascular Cohort (i3C) Consortium
Venn Alison
Daniels Stephen R
Woo Jessica G
Urbina Elaine M
Juonala Markus
Murdy Kari A
Prineas Ronald J
Steinberger Julia
Jacobs David R
Dwyer Terry
Burns Trudy L
Hutri-Kähonen Nina
Sinaiko Alan R
Bazzano Lydia A
Raitakari Olli T
Hu Tian
AMER DIABETES ASSOC
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042823855
https://urn.fi/URN:NBN:fi-fe2021042823855
Tiivistelmä
OBJECTIVE
To examine childhood BMI, fasting glucose, and insulin in relation to incident adult type 2 diabetes mellitus (T2DM).
RESEARCH DESIGN AND METHODS
We used data from the International Childhood Cardiovascular Cohort (i3C) Consortium. Data included childhood (age 3-19 years) measurements obtained during the 1970s-1990s; a health questionnaire, including self-report of adult T2DM (occurrence age, medication use) obtained at mean age 40 years; and a medical diagnosis registry (Finland).
RESULTS
The sample included 6,738 participants. Of these, 436 (6.5%) reported onset of T2DM between ages 20 and 59 (mean 40.8) years, and 86% of them reported use of a confirmed antidiabetic medication. BMI and glucose (age and sex standardized) were associated with incident T2DM after adjustment for cohort, country, sex, race, age, and calendar year of measurement. Increasing levels of childhood BMI and glucose were related to an incrementally increased risk of T2DM beginning at age 30 years, beginning at cut points <95th percentile for BMI and <100 mg/dL for glucose. Insulin was positively associated with adult T2DM after adjustment for BMI and glucose and added to T2DM discrimination.
CONCLUSIONS
Childhood BMI and glucose are predictors of adult T2DM at levels previously considered to be within the normal range. These easy-to-apply measurements are appealing from a clinical perspective. Fasting insulin has the potential to be an additional predictor.
Kokoelmat
- Rinnakkaistallenteet [19207]