Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
Gago-Dominguez Manuela; Parent Marie-Élise; Claessens Frank; Wolk Alicja; Roobol Monique J.; Andreassen Ole A.; Berndt Sonja I.; Eeles Rosalind A.; Pashayan Nora; Martinez Maria Elena; Sanderson Maureen; Travis Ruth C.; West Catharine M.L.; Neuhausen Susan L.; Pandha Hardev; Watya Stephen; Koutros Stella; Ingles Sue A.; Cannon-Albright Lisa; De Ruyck Kim; Thibodeau Stephen N.; Cybulski Cezary; Martin Richard M.; Schleutker Johanna; Hamilton Robert J.; Cussenot Olivier; Albanes Demetrius; Logothetis Christopher J.; Multigner Luc; Zheng Wei; Hamdy Freddie C.; Kibel Adam S.; Grindedal Eli Marie; Usmani Nawaid; John Esther M.; Townsend Paul A.; Park Jong Y.; Lu Yong-Jie; Huff Chad; Dale Anders M.; Hu Jennifer J.; Penney Kathryn L.; Tangen Catherine M.; Gamulin Marija; Rosenstein Barry S.; Bush William S.; Donovan Jenny L.; Sørensen Karina Dalsgaard; Neal David E.; Teixeira Manuel R.; Mucci Lorelei A.; Fan Chun Chieh; Vega Ana; Stanford Janet L.; Kaneva Radka; Nordestgaard Børge G.; Nielsen Sune F.; Leach Robin J.; Khaw Kay-Tee; Mills Ian G.; Fowke Jay H.; Blot William J.; Maier Christiane; Muir Kenneth; Thompson Wesley K.; Brenner Hermann; Menegaux Florence; Razack Azad; Huynh-Le Minh-Phuong; Newcomb Lisa F.; Kogevinas Manolis; Giles Graham G.; Batra Jyotsna; Grönberg Henrik; Karunamuni Roshan; Kote-Jarai Zsofia; Seibert Tyler M.; collaborators UKGPCS; APCB (Australian Prostate Cancer BioResource); NC-LA PCaP Investigators; The IMPACT Study Steering Committee and Collaborators; Canary PASS Investigators; The Profile Study Steering Committee; The PRACTICAL Consortium; Wiklund Fredrik
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
Gago-Dominguez Manuela
Parent Marie-Élise
Claessens Frank
Wolk Alicja
Roobol Monique J.
Andreassen Ole A.
Berndt Sonja I.
Eeles Rosalind A.
Pashayan Nora
Martinez Maria Elena
Sanderson Maureen
Travis Ruth C.
West Catharine M.L.
Neuhausen Susan L.
Pandha Hardev
Watya Stephen
Koutros Stella
Ingles Sue A.
Cannon-Albright Lisa
De Ruyck Kim
Thibodeau Stephen N.
Cybulski Cezary
Martin Richard M.
Schleutker Johanna
Hamilton Robert J.
Cussenot Olivier
Albanes Demetrius
Logothetis Christopher J.
Multigner Luc
Zheng Wei
Hamdy Freddie C.
Kibel Adam S.
Grindedal Eli Marie
Usmani Nawaid
John Esther M.
Townsend Paul A.
Park Jong Y.
Lu Yong-Jie
Huff Chad
Dale Anders M.
Hu Jennifer J.
Penney Kathryn L.
Tangen Catherine M.
Gamulin Marija
Rosenstein Barry S.
Bush William S.
Donovan Jenny L.
Sørensen Karina Dalsgaard
Neal David E.
Teixeira Manuel R.
Mucci Lorelei A.
Fan Chun Chieh
Vega Ana
Stanford Janet L.
Kaneva Radka
Nordestgaard Børge G.
Nielsen Sune F.
Leach Robin J.
Khaw Kay-Tee
Mills Ian G.
Fowke Jay H.
Blot William J.
Maier Christiane
Muir Kenneth
Thompson Wesley K.
Brenner Hermann
Menegaux Florence
Razack Azad
Huynh-Le Minh-Phuong
Newcomb Lisa F.
Kogevinas Manolis
Giles Graham G.
Batra Jyotsna
Grönberg Henrik
Karunamuni Roshan
Kote-Jarai Zsofia
Seibert Tyler M.; collaborators UKGPCS; APCB (Australian Prostate Cancer BioResource); NC-LA PCaP Investigators; The IMPACT Study Steering Committee and Collaborators; Canary PASS Investigators; The Profile Study Steering Committee; The PRACTICAL Consortium
Wiklund Fredrik
NATURE RESEARCH
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042823868
https://urn.fi/URN:NBN:fi-fe2021042823868
Tiivistelmä
Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score >= 7, stage T3-T4, PSA >= 10ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n=71,856), Asian (n=2,382), and African (n=6,253) genetic ancestries (p<10(-180)). Comparing the 80(th)/20(th) PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset. A polygenic hazard score (PHS1) improves prostate cancer screening accuracy in European patients. Here, the authors test the performance of a version compatible with OncoArray genotypes (PHS2) in a multi-ethnic dataset and find that it risk-stratifies men for any, aggressive, and fatal prostate cancer.
Kokoelmat
- Rinnakkaistallenteet [19207]