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Beta cell function in participants with single or multiple islet autoantibodies at baseline in the TEDDY Family Prevention Study: TEFA

Tossavainen Päivi; Martinez Maria Månsson; Katsarou Anastasia; Borg Henrik; Kero Jukka; Maziarz Marlena; Lernmark Åke; Törn Carina; The TEDDY Family (TEFA) Study Group; Veijola Riitta; Larsson Helena Elding; Koskenniemi Jaakko J.; Salami Falastin; Toppari Jorma; Lundgren Markus

Beta cell function in participants with single or multiple islet autoantibodies at baseline in the TEDDY Family Prevention Study: TEFA

Tossavainen Päivi
Martinez Maria Månsson
Katsarou Anastasia
Borg Henrik
Kero Jukka
Maziarz Marlena
Lernmark Åke
Törn Carina; The TEDDY Family (TEFA) Study Group
Veijola Riitta
Larsson Helena Elding
Koskenniemi Jaakko J.
Salami Falastin
Toppari Jorma
Lundgren Markus
Katso/Avaa
Publisher's PDF (476.7Kb)
Lataukset: 

Wiley
doi:10.1002/edm2.198
URI
https://onlinelibrary.wiley.com/doi/10.1002/edm2.198
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021093048827
Tiivistelmä

Aim

The aim of the present study was to assess beta cell function based on an oral glucose tolerance test (OGTT) in participants with single islet autoantibody or an intravenous glucose tolerance test (IvGTT) in participants with multiple islet autoantibodies.

Materials and methods

Healthy participants in Sweden and Finland, between 2 and 49.99 years of age previously identified as positive for a single (n = 30) autoantibody to either insulin, glutamic acid decarboxylase, islet antigen-2, zinc transporter 8 or islet cell antibodies or multiple autoantibodies (n = 46), were included. Participants positive for a single autoantibody underwent a 6-point OGTT while participants positive for multiple autoantibodies underwent an IvGTT. Glucose, insulin and C-peptide were measured from OGTT and IvGTT samples.

Results

All participants positive for a single autoantibody had a normal glucose tolerance test with 120 minutes glucose below 7.70 mmol/L and HbA1c values within the normal range (<42 mmol/mol). Insulin responses to the glucose challenge on OGTT ranged between 13.0 and 143 mIU/L after 120 minutes with C-peptide values between 0.74 and 4.60 nmol/L. In Swedish participants, the first-phase insulin response (FPIR) on IvGTT was lower in those positive for three or more autoantibodies (n = 13; median 83.0 mIU/L; range 20.0-343) compared to those with two autoantibodies (n = 15; median 146 mIU/L; range 19.0-545; P = .0330).

Conclusion

Participants positive for a single autoantibody appeared to have a normal beta cell function. Participants positive for three or more autoantibodies had a lower FPIR as compared to participants with two autoantibodies, supporting the view that their beta cell function had deteriorated.

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