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Children's erythrocyte fatty acids are associated with the risk of islet autoimmunity

Uusitalo Ulla; Hummel Sandra; Toppari Jorma; Sakhanenko Nikita; Parikh Hemang M; Lee Hye-Seung; Lernmark Åke; Aronsson Carin Andén; Liu Xiang; Krischer Jeffrey P; Rewers Marian; Das Siba; Galas David; Hagopian William; She Jin-Xiong; Akolkar Beena; Rich Stephen S; Niinistö Sari; Virtanen Suvi M; the TEDDY Study Group; Norris Jill M; Erlund Iris; Ziegler Annette G; Salminen Irma

Children's erythrocyte fatty acids are associated with the risk of islet autoimmunity

Uusitalo Ulla
Hummel Sandra
Toppari Jorma
Sakhanenko Nikita
Parikh Hemang M
Lee Hye-Seung
Lernmark Åke
Aronsson Carin Andén
Liu Xiang
Krischer Jeffrey P
Rewers Marian
Das Siba
Galas David
Hagopian William
She Jin-Xiong
Akolkar Beena
Rich Stephen S
Niinistö Sari
Virtanen Suvi M; the TEDDY Study Group
Norris Jill M
Erlund Iris
Ziegler Annette G
Salminen Irma
Katso/Avaa
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NATURE RESEARCH
doi:10.1038/s41598-021-82200-9
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042824164
Tiivistelmä
Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in theYoung Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case-control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n - 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n -3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity.
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