Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity
Kieff E; Ahlfors H; Matikainen S; Carter KL; Ruuska M; Rainio EM; Koskinen PJ
Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity
Kieff E
Ahlfors H
Matikainen S
Carter KL
Ruuska M
Rainio EM
Koskinen PJ
ACADEMIC PRESS INC ELSEVIER SCIENCE
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042718112
https://urn.fi/URN:NBN:fi-fe2021042718112
Tiivistelmä
Latent Epstein-Barr virus (EBV) infection is strongly associated with B-cell proliferative diseases such as Burkitt's lymphoma. Here we show that the oncogenic serine/threonine kinases Pim-1 and Pim-2 enhance the activity of the viral transcriptional activator EBNA2. During EBV infection of primary B-lymphocytes, the mRNA expression levels of pint genes, especially of pim-2, are upregulated and remain elevated in latently infected B-cell lines. Thus, EBV-induced upregulation of Pim kinases and Pim-stimulated EBNA2 transcriptional activity may contribute to the ability of EBV to immortalize B-cells and predispose them to malignant growth. (C) 2005 Elsevier Inc. All rights reserved.
Kokoelmat
- Rinnakkaistallenteet [19207]