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Prebiotic Xylo-Oligosaccharides Ameliorate High-Fat-Diet-Induced Hepatic Steatosis in Rats

Raghunath Pariyani; Baoru Yang; Leo Lahti; Anastasiia Driuchina; Sanna Lensu; Elina Mäkinen; Satu Pekkala; Wisam Saleem; Maarit Lehti; Jere Linden; Eveliina Munukka; Marja Tiirola

dc.contributor.authorRaghunath Pariyani
dc.contributor.authorBaoru Yang
dc.contributor.authorLeo Lahti
dc.contributor.authorAnastasiia Driuchina
dc.contributor.authorSanna Lensu
dc.contributor.authorElina Mäkinen
dc.contributor.authorSatu Pekkala
dc.contributor.authorWisam Saleem
dc.contributor.authorMaarit Lehti
dc.contributor.authorJere Linden
dc.contributor.authorEveliina Munukka
dc.contributor.authorMarja Tiirola
dc.date.accessioned2022-10-28T13:55:00Z
dc.date.available2022-10-28T13:55:00Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/168256
dc.description.abstract<p>Understanding the importance of the gut microbiota (GM) in non-alcoholic fatty liver disease (NAFLD) has raised the hope for therapeutic microbes. We have shown that high hepatic fat content associated with low abundance of Faecalibacterium prausnitzii in humans and, further, the administration of F. prausnitziiprevented NAFLD in mice. Here, we aimed at targeting F. prausnitzii by prebiotic xylo-oligosaccharides (XOS) to treat NAFLD. First, the effect of XOS on F. prausnitzii growth was assessed in vitro. Then, XOS was supplemented or not with high (HFD, 60% of energy from fat) or low (LFD) fat diet for 12 weeks in Wistar rats (n = 10/group). XOS increased F. prausnitzii growth, having only a minor impact on the GM composition. When supplemented with HFD, XOS ameliorated hepatic steatosis. The underlying mechanisms involved enhanced hepatic β-oxidation and mitochondrial respiration. Nuclear magnetic resonance (<sup>1</sup>H-NMR) analysis of cecal metabolites showed that, compared to the HFD, the LFD group had a healthier cecal short-chain fatty acid profile and on the HFD, XOS reduced cecal isovalerate and tyrosine, metabolites previously linked to NAFLD. Cecal branched-chain fatty acids associated positively and butyrate negatively with hepatic triglycerides. In conclusion, XOS supplementation can ameliorate NAFLD by improving hepatic oxidative metabolism and affecting GM. <br /></p>
dc.language.isoen
dc.publisherMDPI
dc.titlePrebiotic Xylo-Oligosaccharides Ameliorate High-Fat-Diet-Induced Hepatic Steatosis in Rats
dc.identifier.urnURN:NBN:fi-fe2021042824243
dc.relation.volume12
dc.contributor.organizationfi=biolääketieteen laitos, yhteiset|en=Institute of Biomedicine|
dc.contributor.organizationfi=lääket. tdk yhteiset|en=Lääket. tdk yhteiset|
dc.contributor.organizationfi=väestötutkimuskeskus|en=Centre for Population Health Research (POP Centre)|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organizationfi=PÄÄT Elintarvikekemia ja elintarvikekehitys|en=PÄÄT Food Chemistry and Food Development|
dc.contributor.organizationfi=PÄÄT Kieli- ja puheteknologia|en=PÄÄT Language and Speech Technology|
dc.contributor.organization-code2606204
dc.contributor.organization-code2606805
dc.contributor.organization-code2607100
dc.contributor.organization-code2607008
dc.contributor.organization-code2607000
dc.converis.publication-id50060869
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/50060869
dc.identifier.eissn2072-6643
dc.identifier.jour-issn2072-6643
dc.okm.affiliatedauthorTariq Saleem, Wisam
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorPariyani, Raghunath
dc.okm.affiliatedauthorMunukka, Eveliina
dc.okm.affiliatedauthorPekkala, Satu
dc.okm.affiliatedauthorYang, Baoru
dc.okm.affiliatedauthorLahti, Leo
dc.okm.discipline1183 Plant biology, microbiology, virologyen_GB
dc.okm.discipline415 Other agricultural sciencesen_GB
dc.okm.discipline3141 Health care scienceen_GB
dc.okm.discipline3141 Terveystiedefi_FI
dc.okm.discipline1183 Kasvibiologia, mikrobiologia, virologiafi_FI
dc.okm.discipline415 Muut maataloustieteetfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countrySwitzerlanden_GB
dc.publisher.countrySveitsifi_FI
dc.publisher.country-codeCH
dc.relation.articlenumber3225
dc.relation.doi10.3390/nu12113225
dc.relation.ispartofjournalNutrients
dc.relation.issue11
dc.year.issued2020


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