dc.contributor.author | Raghunath Pariyani | |
dc.contributor.author | Baoru Yang | |
dc.contributor.author | Leo Lahti | |
dc.contributor.author | Anastasiia Driuchina | |
dc.contributor.author | Sanna Lensu | |
dc.contributor.author | Elina Mäkinen | |
dc.contributor.author | Satu Pekkala | |
dc.contributor.author | Wisam Saleem | |
dc.contributor.author | Maarit Lehti | |
dc.contributor.author | Jere Linden | |
dc.contributor.author | Eveliina Munukka | |
dc.contributor.author | Marja Tiirola | |
dc.date.accessioned | 2022-10-28T13:55:00Z | |
dc.date.available | 2022-10-28T13:55:00Z | |
dc.identifier.uri | https://www.utupub.fi/handle/10024/168256 | |
dc.description.abstract | <p>Understanding the importance of the gut microbiota (GM) in non-alcoholic fatty liver disease (NAFLD) has raised the hope for therapeutic microbes. We have shown that high hepatic fat content associated with low abundance of Faecalibacterium prausnitzii in humans and, further, the administration of F. prausnitziiprevented NAFLD in mice. Here, we aimed at targeting F. prausnitzii by prebiotic xylo-oligosaccharides (XOS) to treat NAFLD. First, the effect of XOS on F. prausnitzii growth was assessed in vitro. Then, XOS was supplemented or not with high (HFD, 60% of energy from fat) or low (LFD) fat diet for 12 weeks in Wistar rats (n = 10/group). XOS increased F. prausnitzii growth, having only a minor impact on the GM composition. When supplemented with HFD, XOS ameliorated hepatic steatosis. The underlying mechanisms involved enhanced hepatic β-oxidation and mitochondrial respiration. Nuclear magnetic resonance (<sup>1</sup>H-NMR) analysis of cecal metabolites showed that, compared to the HFD, the LFD group had a healthier cecal short-chain fatty acid profile and on the HFD, XOS reduced cecal isovalerate and tyrosine, metabolites previously linked to NAFLD. Cecal branched-chain fatty acids associated positively and butyrate negatively with hepatic triglycerides. In conclusion, XOS supplementation can ameliorate NAFLD by improving hepatic oxidative metabolism and affecting GM. <br /></p> | |
dc.language.iso | en | |
dc.publisher | MDPI | |
dc.title | Prebiotic Xylo-Oligosaccharides Ameliorate High-Fat-Diet-Induced Hepatic Steatosis in Rats | |
dc.identifier.urn | URN:NBN:fi-fe2021042824243 | |
dc.relation.volume | 12 | |
dc.contributor.organization | fi=biolääketieteen laitos, yhteiset|en=Institute of Biomedicine| | |
dc.contributor.organization | fi=lääket. tdk yhteiset|en=Lääket. tdk yhteiset| | |
dc.contributor.organization | fi=väestötutkimuskeskus|en=Centre for Population Health Research (POP Centre)| | |
dc.contributor.organization | fi=tyks, vsshp|en=tyks, vsshp| | |
dc.contributor.organization | fi=PÄÄT Elintarvikekemia ja elintarvikekehitys|en=PÄÄT Food Chemistry and Food Development| | |
dc.contributor.organization | fi=PÄÄT Kieli- ja puheteknologia|en=PÄÄT Language and Speech Technology| | |
dc.contributor.organization-code | 2606204 | |
dc.contributor.organization-code | 2606805 | |
dc.contributor.organization-code | 2607100 | |
dc.contributor.organization-code | 2607008 | |
dc.contributor.organization-code | 2607000 | |
dc.converis.publication-id | 50060869 | |
dc.converis.url | https://research.utu.fi/converis/portal/Publication/50060869 | |
dc.identifier.eissn | 2072-6643 | |
dc.identifier.jour-issn | 2072-6643 | |
dc.okm.affiliatedauthor | Tariq Saleem, Wisam | |
dc.okm.affiliatedauthor | Dataimport, tyks, vsshp | |
dc.okm.affiliatedauthor | Pariyani, Raghunath | |
dc.okm.affiliatedauthor | Munukka, Eveliina | |
dc.okm.affiliatedauthor | Pekkala, Satu | |
dc.okm.affiliatedauthor | Yang, Baoru | |
dc.okm.affiliatedauthor | Lahti, Leo | |
dc.okm.discipline | 1183 Plant biology, microbiology, virology | en_GB |
dc.okm.discipline | 415 Other agricultural sciences | en_GB |
dc.okm.discipline | 3141 Health care science | en_GB |
dc.okm.discipline | 3141 Terveystiede | fi_FI |
dc.okm.discipline | 1183 Kasvibiologia, mikrobiologia, virologia | fi_FI |
dc.okm.discipline | 415 Muut maataloustieteet | fi_FI |
dc.okm.internationalcopublication | not an international co-publication | |
dc.okm.internationality | International publication | |
dc.okm.type | Journal article | |
dc.publisher.country | Switzerland | en_GB |
dc.publisher.country | Sveitsi | fi_FI |
dc.publisher.country-code | CH | |
dc.relation.articlenumber | 3225 | |
dc.relation.doi | 10.3390/nu12113225 | |
dc.relation.ispartofjournal | Nutrients | |
dc.relation.issue | 11 | |
dc.year.issued | 2020 | |