Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes
AMER CHEMICAL SOC
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Tiivistelmä
A phthaloyl-protected aminooxymethyl-C-2'-deoxyriboside building block has been prepared and incorporated in the middle of an oligodeoxyribonucleotide. Removal of the phthaloyl protection followed by on-support oximation with either mercurated or palladated benzaldehydes yielded oligonucleotides bearing the respective benzaldoxime metallacycles.