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Contractility-dependent actin dynamics in cardiomyocyte sarcomeres

Lappalainen P; Skwarek-Maruszewska A; Mattila PK; Hotulainen P

dc.contributor.authorLappalainen P
dc.contributor.authorSkwarek-Maruszewska A
dc.contributor.authorMattila PK
dc.contributor.authorHotulainen P
dc.date.accessioned2022-10-28T13:58:44Z
dc.date.available2022-10-28T13:58:44Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/168653
dc.description.abstractIn contrast to the highly dynamic actin cytoskeleton in nonmuscle cells, actin filaments in muscle sarcomeres are thought to be relatively stable and undergo dynamics only at their ends. However, many proteins that promote rapid actin dynamics are also expressed in striated muscles. We show that a subset of actin filaments in cardiomyocyte sarcomeres displays rapid turnover. Importantly, we found that turnover of these filaments depends on contractility of the cardiomyocytes. Studies using an actin-polymerization inhibitor suggest that the pool of dynamic actin filaments is composed of filaments that do not contribute to contractility. Furthermore, we provide evidence that ADF/cofilins, together with myosin-induced contractility, are required to disassemble non-productive filaments in developing cardiomyocytes. These data indicate that an excess of actin filaments is produced during sarcomere assembly, and that contractility is applied to recognize non-productive filaments that are subsequently destined for depolymerization. Consequently, contractility-induced actin dynamics plays an important role in sarcomere maturation.
dc.publisherCOMPANY OF BIOLOGISTS LTD
dc.titleContractility-dependent actin dynamics in cardiomyocyte sarcomeres
dc.identifier.urnURN:NBN:fi-fe2021042715295
dc.relation.volume122
dc.contributor.organizationfi=PÄÄT Patologia ja oikeuslääketiede|en=PÄÄT Patologia ja oikeuslääketiede|
dc.contributor.organization-code2607107
dc.converis.publication-id3727644
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/3727644
dc.format.pagerange2119
dc.format.pagerange2126
dc.identifier.jour-issn0021-9533
dc.okm.affiliatedauthorMattila, Pieta
dc.okm.discipline1182 Biokemia, solu- ja molekyylibiologiafi_FI
dc.okm.discipline1182 Biochemistry, cell and molecular biologyen_GB
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.relation.doi10.1242/jcs.046805
dc.relation.ispartofjournalJournal of Cell Science
dc.relation.issue12
dc.year.issued2009


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