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Trends in Cardiometabolic and Cancer Multimorbidity Prevalence and Its Risk With All-Cause and Cause-Specific Mortality in U.S. Adults: Prospective Cohort Study

Sun Jiahong; Yang Liu; Zhao Min; Xi Bo; Magnussen Costan G.

dc.contributor.authorSun Jiahong
dc.contributor.authorYang Liu
dc.contributor.authorZhao Min
dc.contributor.authorXi Bo
dc.contributor.authorMagnussen Costan G.
dc.date.accessioned2022-10-28T14:03:57Z
dc.date.available2022-10-28T14:03:57Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/169146
dc.description.abstractSeveral prospective cohort studies have assessed the association between multimorbidity and all-cause mortality, but the findings have been inconsistent. In addition, limited studies have assessed the association between multimorbidity and cause-specific mortality. In this study, we used the population based cohort study of National Health Interview Survey (1997-2014) with linkage to the National Death Index records to 31 December 2015 to examine the trends in prevalence of multimorbidity from 1997 to 2014, and its association with the risk of all-cause and cause-specific mortality in the U.S. population. A total of 372,566 adults aged 30-84 years were included in this study. From 1997 to 2014, the age-standardized prevalence of specific chronic condition and multimorbidity increased significantly (P < 0.0001). During a median follow-up of 9.0 years, 50,309 of 372,566 participants died from all causes, of which 11,132 (22.1%) died from CVD and 13,170 (26.2%) died from cancer. Compared with participants without the above-mentioned chronic conditions, those with 1, 2, 3, and >= 4 of chronic conditions had 1.41 (1.37-1.45), 1.94 (1.88-2.00), 2.64 (2.54-2.75), and 3.68 (3.46-3.91) higher risk of all-cause mortality after adjustment for important covariates. Similarly, a higher risk of CVD-specific and cancer-specific mortality was observed as the number of chronic conditions increased, with the observed risk stronger for CVD-mortality compared with cancer-specific mortality. Given the prevalence of multimorbidity tended to increase from 1997 to 2014, our data suggest effective prevention and intervention programs are necessary to limit the increased mortality risk associated with multimorbidity.
dc.language.isoen
dc.publisherFRONTIERS MEDIA SA
dc.titleTrends in Cardiometabolic and Cancer Multimorbidity Prevalence and Its Risk With All-Cause and Cause-Specific Mortality in U.S. Adults: Prospective Cohort Study
dc.identifier.urlhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.731240/full
dc.identifier.urnURN:NBN:fi-fe2022012710955
dc.relation.volume8
dc.contributor.organizationfi=sydäntutkimuskeskus|en=Research Centre of Applied and Preventive Cardiovascular Medicine (CAPC)|
dc.contributor.organizationfi=väestötutkimuskeskus|en=Centre for Population Health Research (POP Centre)|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organization-code2607008
dc.contributor.organization-code2607004
dc.converis.publication-id68707542
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/68707542
dc.identifier.eissn2297-055X
dc.identifier.jour-issn2297-055X
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorMagnussen, Costan
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countrySveitsifi_FI
dc.publisher.countrySwitzerlanden_GB
dc.publisher.country-codeCH
dc.relation.articlenumberARTN 731240
dc.relation.doi10.3389/fcvm.2021.731240
dc.relation.ispartofjournalFrontiers in Cardiovascular Medicine
dc.year.issued2021


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