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Emerging histopathologic markers in early-stage oral tongue cancer: A systematic review and meta-analysis

Mäkitie Antti A.; Salo Tuula; Elseragy Amr; Bello Ibrahim O.; Wahab Awais; Coletta Ricardo D.; Leivo Ilmo; Almangush Alhadi

Emerging histopathologic markers in early-stage oral tongue cancer: A systematic review and meta-analysis

Mäkitie Antti A.
Salo Tuula
Elseragy Amr
Bello Ibrahim O.
Wahab Awais
Coletta Ricardo D.
Leivo Ilmo
Almangush Alhadi
Katso/Avaa
LeivoEtAl2022EmergingHistopathologicMarkers.pdf (5.638Mb)
Lataukset: 

WILEY
doi:10.1002/hed.27022
URI
https://onlinelibrary.wiley.com/doi/10.1002/hed.27022
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022081154812
Tiivistelmä

Although there are many histopathologic prognosticators, grading of early oral tongue squamous cell carcinoma (OTSCC) is still based on morphological cell differentiation which has low prognostic value. Here we summarize the emerging histopathological markers showing powerful prognostic value, but are not included in pathology reports. Using PubMed, Scopus, Ovid Medline, and Web of Science databases, a systematic literature search was preformed to identify early OTSCC studies that investigated the prognostic significance of hematoxylin-eosin-based histopathologic markers. Our meta-analysis showed that tumor budding was associated with overall survival (hazard ratio [HR] 2.32; 95% CI 1.40-3.84; p < 0.01) and disease-specific survival (DSS) (1.89; 95% CI 1.13-3.15; p = 0.02). Worst pattern of invasion was associated with disease-free survival (DFS) (1.95; 95% CI 1.04-3.64; p = 0.04). Tumor-stroma ratio was also associated with DFS (1.75, 95% CI 1.24-2.48; p < 0.01) and DSS (1.69; 95% CI 1.19-2.42; p < 0.01). Tumor budding, worst pattern of invasion, and tumor-stroma ratio have a promising prognostic value in early OTSCC. The evaluation and reporting of these markers is cost-effective and can be incorporated in daily practice.

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