Bioavailability of docosahexaenoic acid 22:6(n-3) from enantiopure triacylglycerols and their regioisomeric counterpart in rats
Zhang Yumei; Kulkarni Amruta; Magnusson Johann D.; Linderborg Kaisa M.; Yang Baoru; Zhao Ai; Zhang Jian; Haraldsson Gudmundur G.; Kallio Heikki
Bioavailability of docosahexaenoic acid 22:6(n-3) from enantiopure triacylglycerols and their regioisomeric counterpart in rats
Zhang Yumei
Kulkarni Amruta
Magnusson Johann D.
Linderborg Kaisa M.
Yang Baoru
Zhao Ai
Zhang Jian
Haraldsson Gudmundur G.
Kallio Heikki
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042825008
https://urn.fi/URN:NBN:fi-fe2021042825008
Tiivistelmä
Lack of synthetic enantiospecific triacylglycerols (TAGs) has hindered our understanding of the impact of TAG structure on the absorption and metabolic fate of fatty acids (FAs). In a five-day feeding trial with mildly (n-3) deficient rats, the bioavailability of docosahexaenoic acid [22:6(n-3), DHA] and stearic acid (18:0) from the two different enantiomers of TAG: sn-22:6(n-3)-18:0-18:0 and sn-18:0-18:0-22:6(n-3), and their regioisomeric TAG: sn-18:0-22:6(n-3)-18:0 was compared. Less secretion of fecal DHA was detected from the sn-2 position compared with the sn-1 and sn-3 positions, but no difference was found in DHA content of the fasting plasma or in the weight of the body or organs. 18:0 was lost to feces mainly as cleaved from the primary positions but also as glycerol-bound. The 5-day intervention in rats was long enough to modify the fatty acid profile of plasma phospholipids.
Kokoelmat
- Rinnakkaistallenteet [19207]